Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.38 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | NNMT | P40261 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20731980 | 0.84 | USP28 (0.39) | KDM4EALDH1A1SMN1; SMN2KMT2ACYP1A2 | |
| SCHEMBL20731005 | 0.78 | ALDH1A1 (0.62) | KDM4EALDH1A1SMN1; SMN2KMT2AIKBKB | |
| SCHEMBL24729646 | 0.78 | ALDH1A1 (0.45) | KDM4EALDH1A1SMN1; SMN2KMT2AIKBKB | |
| SCHEMBL20722419 | 0.76 | LIMK1 (0.51) | KDM4EALDH1A1SMN1; SMN2KMT2ACYP1A2 | |
| SCHEMBL30968434 | 0.76 | LIMK1 (0.51) | KDM4EALDH1A1SMN1; SMN2KMT2ACYP1A2 | |
| SCHEMBL7844211 | 0.75 | KDM4E (0.59) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL30968442 | 0.75 | KDM4E (0.59) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL23938107 | 0.75 | KDM4E (0.42) | KDM4EALDH1A1SMN1; SMN2KMT2AIKBKB | |
| SCHEMBL23937998 | 0.70 | KMT2A (0.38) | ALDH1A1SMN1; SMN2KMT2ACYP1A2USP28 | |
| SCHEMBL19737518 | 0.69 | MAPT (0.56) | KDM4EALDH1A1SMN1; SMN2KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11524966-B1 | Carboxamides as ubiquitin-specific protease inhibitors | VALO HEALTH, INC. (US) | 2022-12-13 | — | — | US | disclosed |
| US-20210323975-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | VALO EARLY DISCOVERY, INC. | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11524966-B1 | Carboxamides as ubiquitin-specific protease inhibitors | USP28, USP25, USP24 | KDM4E 403/4885ALDH1A1 2167/4885SMN1; SMN2 2918/4885 |
| US-20210323975-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | USP28, USP25, USP24 | KDM4E 403/4885ALDH1A1 2167/4885SMN1; SMN2 2918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.