Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 14/20 | 0.58 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.54 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21753384 | 0.74 | P2RX7 (1.00) | P2RX7P2RY12 | |
| SCHEMBL21753443 | 0.73 | P2RX7 (1.00) | P2RX7P2RY12 | |
| SCHEMBL21753383 | 0.71 | P2RX7 (1.00) | P2RX7P2RY12TYK2HPGD | |
| SCHEMBL21769578 | 0.70 | P2RX7 (0.72) | P2RX7P2RY12TYK2 | |
| SCHEMBL4885873 | 0.69 | P2RX7 (1.00) | P2RX7P2RY12 | |
| SCHEMBL23950059 | 0.69 | P2RX7 (0.67) | P2RX7P2RY12 | |
| SCHEMBL23949843 | 0.66 | P2RX7 (0.85) | P2RX7P2RY12TYK2 | |
| SCHEMBL21769898 | 0.66 | P2RX7 (0.70) | P2RX7P2RY12TYK2 | |
| SCHEMBL23949851 | 0.66 | P2RX7 (0.85) | P2RX7P2RY12 | |
| SCHEMBL7517506 | 0.66 | P2RX7 (0.57) | P2RX7P2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210323910-A1 | ADAMANTANYL-SUBSTITUTED BENZAMIDE COMPOUNDS AND THEIR USE AS P2X7 RECEPTOR ANTAGONISTS | THE UNIVERSITY OF SYDNEY (AU) | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210323910-A1 | ADAMANTANYL-SUBSTITUTED BENZAMIDE COMPOUNDS AND THEIR USE AS P2X7 RECEPTOR ANTAGONISTS | P2RX1, P2RX3, P2RX5 | P2RX7 4/4885P2RY12 14/4885CCR3 1360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.