Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23927843 | 0.86 | HTR7 (0.48) | HTR7HTR2CMTNR1AMTNR1BHTR2A | |
| SCHEMBL23956108 | 0.85 | HTR7 (0.38) | HTR7HTR2CMTNR1AMTNR1B | |
| SCHEMBL23956096 | 0.82 | HTR7 (0.72) | HTR7HTR2CMTNR1AMTNR1BHTR2A | |
| SCHEMBL23927918 | 0.82 | HTR7 (0.68) | HTR7HTR2CMTNR1AMTNR1BHTR2A | |
| SCHEMBL23956095 | 0.82 | HTR7 (0.67) | HTR7HTR2CMTNR1AMTNR1BHTR2A | |
| SCHEMBL23956139 | 0.82 | HTR7 (0.47) | HTR7HTR2CHTR2APRMT5 | |
| SCHEMBL23927836 | 0.81 | HTR7 (0.67) | HTR7HTR2CMTNR1AMTNR1BHTR2A | |
| SCHEMBL23927917 | 0.77 | HTR7 (0.58) | HTR7HTR2CMTNR1AMTNR1BPRMT5 | |
| SCHEMBL18857020 | 0.76 | HTR2C (0.59) | HTR7HTR2CMTNR1AMTNR1BHTR2A | |
| SCHEMBL18857024 | 0.74 | MTNR1A (0.62) | HTR7HTR2CMTNR1AMTNR1BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11254640-B2 | N-substituted indoles and other heterocycles for treating brain disorders | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-02-22 | — | — | US | disclosed |
| US-20210332012-A1 | N-SUBSTITUTED INDOLES AND OTHER HETEROCYCLES FOR TREATING BRAIN DISORDERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA CORPORATION | 2021-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11254640-B2 | N-substituted indoles and other heterocycles for treating brain disorders | TPH2, AANAT, HTR2C | HTR7 32/4885HTR2C 3/4885MTNR1A 61/4885 |
| US-20210332012-A1 | N-SUBSTITUTED INDOLES AND OTHER HETEROCYCLES FOR TREATING BRAIN DISORDERS | TPH2, AANAT, HTR2C | HTR7 32/4885HTR2C 3/4885MTNR1A 61/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.