Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.64 |
| ▸ | PGR | P06401 | 1/20 | 0.56 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL301661 | 0.80 | LMNA (0.70) | KEAP1PGRNR3C2LMNAKDM4E | |
| SCHEMBL56693 | 0.80 | KEAP1 (1.00) | KEAP1PGRNR3C2LMNAKDM4E | |
| Fluoride SCHEMBL28258745 | 0.78 | KEAP1 (0.95) | KEAP1PGRNR3C2LMNAKDM4E | |
| SCHEMBL11512295 | 0.78 | KEAP1 (0.95) | KEAP1PGRNR3C2LMNAKDM4E | |
| Hydrogen Sulfide SCHEMBL27698561 | 0.78 | KEAP1 (0.95) | KEAP1PGRNR3C2LMNAKDM4E | |
| Hydrochloric Acid SCHEMBL27365433 | 0.78 | KEAP1 (0.95) | KEAP1PGRNR3C2LMNAKDM4E | |
| SCHEMBL2840269 | 0.77 | HDAC4 (0.64) | KEAP1PGRNR3C2LMNAKDM4E | |
| SCHEMBL8486918 | 0.77 | LMNA (0.63) | KEAP1PGRNR3C2LMNAKDM4E | |
| SCHEMBL4442941 | 0.77 | CA12 (0.55) | KEAP1PGRNR3C2LMNAKDM4E | |
| SCHEMBL2002046 | 0.77 | CA12 (0.55) | KEAP1PGRNR3C2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021214048-A1 | DUAL INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE AND 5-LIPOXYGENASE | Johann Wolfgang Goethe-Universität Frankfurt am Main (DE) | 2021-10-28 | — | — | WO | disclosed |