Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10900625 | 0.84 | HSP90AA1 (0.71) | HSP90AB1HSP90AA1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL24253736 | 0.83 | HSP90AB1 (0.41) | HSP90AB1HSP90AA1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL29566785 | 0.78 | HSD17B10 (0.55) | HSP90AB1HSP90AA1KDM4EHSD17B10KMT2A | |
| SCHEMBL8058901 | 0.78 | ADORA2A (0.44) | HSP90AB1HSP90AA1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL5748941 | 0.78 | HSD17B10 (0.55) | HSP90AB1HSP90AA1KDM4EHSD17B10KMT2A | |
| SCHEMBL29762932 | 0.78 | ADORA2A (0.44) | HSP90AB1HSP90AA1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL628056 | 0.77 | NT5E (0.39) | HSP90AB1HSP90AA1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL5788589 | 0.77 | HSP90AA1 (0.63) | HSP90AB1HSP90AA1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL6294671 | 0.76 | NT5E (0.38) | HSP90AB1HSP90AA1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL140640 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117567498-A | Sodium hydride suspension and application thereof in flow chemical reaction | 武汉药明康德新药开发有限公司 | 2024-02-20 | — | — | CN | claimed |
| CN-117069063-A | Sodium hydride suspension and application thereof in flow chemical reaction | 武汉药明康德新药开发有限公司 | 2023-11-17 | — | — | CN | claimed |
| US-11773067-B2 | (Trifluoromethyl)pyrimidine-2-amine compounds | ELI LILLY AND COMPANY (US) | 2023-10-03 | — | — | US | claimed |
| US-12630534-B2 | 1-((1H-pyrazol-4-yl)methyl)-3-(phenyl)-1,3-dihydro-2H-imidazol-2-one derivatives and related compounds as GPR139 antagonists for the treatment of e.g. depression | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2026-05-19 | — | — | US | disclosed |
| WO-2025224010-A1 | IMPROVED O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE SUBSTRATES | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V. (DE) | 2025-10-30 | — | — | WO | disclosed |
| US-20250092042-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2025-03-20 | — | — | US | disclosed |
| US-20250002461-A1 | DEUTERATED (TRIFLUOROMETHYL)PYRIMIDINE-2-AMINE COMPOUNDS AS POTENTIATORS OF THE HMRGX1 RECEPTOR | ELI LILLY AND COMPANY | 2025-01-02 | — | — | US | disclosed |
| US-12157737-B2 | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | NOVARTIS AG (CH) | 2024-12-03 | — | — | US | disclosed |
| CN-115803321-B | 4- (2, 6-Difluorophenoxy) -6- (trifluoromethyl) pyrimidin-2-amine derivatives as enhancers of HMRGX-receptors for the treatment of pain | 伊莱利利公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-118251381-A | Deuterated (trifluoromethyl) pyrimidin-2-amine compounds as enhancers of HMRGX's 1 receptor | 伊莱利利公司 | 2024-06-25 | — | — | CN | disclosed |
| EP-4146630-B1 | 4-(2,6-DIFLUOROPHENOXY)-6-(TRIFLUOROMETHYL)PYRIMIDIN-2-AMINE DERIVATIVES AS POTENTIATORS OF THE HMRGX1 RECEPTOR FOR THE TREATMENT OF PAIN | LILLY CO ELI (US) | 2024-04-24 | — | — | EP | disclosed |
| US-5952331-A | SELECTIVE 5HT2B ANTAGONISTS; SEROTONIN RECEPTOR ANTAGONIST; TREATING DISORDERS OF THE GASTROINTESTINAL TRACK, RESTENOSIS, ASTHMA AND OBSTRUCTIVE AIRWAY DISEASE, PROSTATIC HYPERPLASIA, GENERALIZED ANXIETY, PANIC DISORDER | SYNTEX (USA) INC. (US) | 1999-09-14 | — | — | US | disclosed |
| CN-1223641-A | Aryl pyrimidine derivatives | HOFFMANN LA ROCHE (CH) | 1999-07-21 | — | — | CN | disclosed |
| EP-0628031-B1 | HERBICIDE N- (PYRIMIDIN-2-YL)AMINOCARBONYL] BENZENE SULPHONAMIDES | BASF AG (DE) | 1999-06-16 | — | — | EP | disclosed |
| EP-0901474-A1 | ARYL PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| US-5863924-A | Aryl pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1999-01-26 | — | — | US | disclosed |
| WO-1997044326-A1 | ARYL PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-27 | — | — | WO | disclosed |
| US-5612286-A | FLUORINE SUBSTITUTED HEERBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1997-03-18 | — | — | US | disclosed |
| EP-0628031-A1 | HERBICIDE N- (PYRIMIDIN-2-YL)AMINOCARBONYL] BENZENE SULPHONAMIDES | BASF Aktiengesellschaft (DE) | 1994-12-14 | — | — | EP | disclosed |
| WO-1993016998-A1 | HERBICIDE N-[(PYRIMIDIN-2-YL)AMINOCARBONYL] BENZENE SULPHONAMIDES | BASF AKTIENGESELLSCHAFT (DE) | 1993-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12157737-B2 | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | REN, NR3C2, PKD1 | HSP90AB1 2143/4885HSP90AA1 2357/4885KDM4E 2714/4885 |
| US-11773067-B2 | (Trifluoromethyl)pyrimidine-2-amine compounds | P2RX1, P2RX2, P2RY1 | HSP90AB1 2427/4885HSP90AA1 2606/4885KDM4E 1718/4885 |
| US-20250092042-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | REN, PKD1, PKD2 | HSP90AB1 2009/4885HSP90AA1 1958/4885KDM4E 2744/4885 |
| US-20250002461-A1 | DEUTERATED (TRIFLUOROMETHYL)PYRIMIDINE-2-AMINE COMPOUNDS AS POTENTIATORS OF THE HMRGX1 RECEPTOR | P2RX1, P2RX2, P2RX3 | HSP90AB1 2519/4885HSP90AA1 2775/4885KDM4E 3250/4885 |
| US-12630534-B2 | 1-((1H-pyrazol-4-yl)methyl)-3-(phenyl)-1,3-dihydro-2H-imidazol-2-one derivatives and related compounds as GPR139 antagonists for the treatment of e.g. depression | GPR139, OPRL1, GRIN2C | HSP90AB1 1924/4885HSP90AA1 2143/4885KDM4E 2423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.