SCHEMBL2396549

SCHEMBL2396549

Cc1nc(N)nc(O)c1Br

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.44
TLR8 Q9NR97 1/20 0.42
ALDH1A1 P00352 7/20 0.41
GAA P10253 1/20 0.41
NR1I2 O75469 1/20 0.40
AHR P35869 1/20 0.40
IKBKB O14920 2/20 0.39
IKBKE Q14164 1/20 0.39
KDM4E B2RXH2 3/20 0.37
MAP3K14 Q99558 1/20 0.35
CYP1A2 P05177 3/20 0.33
HPGD P15428 2/20 0.33
IDO1 P14902 1/20 0.33
NUDT1 P36639 1/20 0.33
HSD17B10 Q99714 1/20 0.33
RAB9A P51151 1/20 0.32
MEN1 O00255 1/20 0.31
USP2 O75604 1/20 0.31
POLB P06746 1/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2234353 0.82 LMNA (0.55) LMNATLR8ALDH1A1GAANR1I2
SCHEMBL13851094 0.77 LMNA (0.56) LMNATLR8ALDH1A1GAANR1I2
SCHEMBL30669887 0.77 LMNA (0.33) LMNAIKBKBMAP3K14CYP1A2
SCHEMBL8081435 0.77 LMNA (0.33) LMNAIKBKBMAP3K14CYP1A2
Bromide SCHEMBL8547428 0.75 LMNA (0.61) LMNATLR8ALDH1A1GAANR1I2
SCHEMBL29464296 0.75 LMNA (0.37) LMNA
SCHEMBL30420099 0.75 ALDH1A1 (0.40) LMNATLR8ALDH1A1GAAKDM4E
SCHEMBL14967319 0.75 LMNA (0.37) LMNAHPGD
SCHEMBL22055454 0.75 LMNA (0.37) LMNA
SCHEMBL12368143 0.75 ALDH1A1 (0.40) LMNATLR8ALDH1A1KDM4ECYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190142792-A1 ANTIVIRAL EPICATECHINS, EPICATECHIN OLIGOMERS, OR THIOLATED EPICATECHINS FROM THEOBROMA CACAO FOR TREATMENT OF GENITAL WARTS CACAO BIO-TECHNOLOGIES, LLC (US) 2019-05-16 US claimed
US-20170035726-A1 ANTIVIRAL EPICATECHINS, EPICATECHIN OLIGOMERS, OR THIOLATED EPICATECHINS FROM THEOBROMA CACAO FOR TREATMENT OF GENITAL WARTS CACAO BIO-TECHNOLOGIES, LLC (US) 2017-02-09 US claimed
US-20150011488-A1 ANTIVIRAL EPICATECHINS, EPICATECHIN OLIGOMERS, OR THIOLATED EPICATECHINS FROM THEOBROMA CACAO FOR TREATMENT OF GENITAL WARTS CACAO BIO-TECHNOLOGIES, LLC (US) 2015-01-08 US claimed
US-20110218241-A1 ANTIVIRAL EPICATECHINS, EPICATECHIN OLIGOMERS, OR THIOLATED EPICATECHINS FROM THEOBROMA CACAO FOR TREATMENT OF GENITAL WARTS CACAO BIO-TECHNOLOGIES, LLC (US) 2011-09-08 US claimed
US-6962695-B1 Modification of interferon alpha production BIONATIVE AB (SE) 2005-11-08 US claimed
EP-1141012-B1 MODIFICATION OF INTERFERON ALPHA PRODUCTION VIRANATIVE AB (SE) 2005-06-29 EP claimed
US-6846525-B2 Recording sheets containing purine, pyrimidine, benzimidazole, imidazolidine, urazole, pyrazole, triazole, benzotriazole, tetrazole, and pyrazine compounds XEROX CORPORATION (US) 2005-01-25 US claimed
US-20040202825-A1 RECORDING SHEETS CONTAINING PURINE, PYRIMIDINE, BENZIMIDAZOLE, IMIDAZOLIDINE, URAZOLE, PYRAZOLE, TRIAZOLE, BENZOTRIAZOLE, TETRAZOLE, AND PYRAZINE COMPOUNDS XEROX CORPORATION 2004-10-14 US claimed
EP-1141012-A1 MODIFICATION OF INTERFERON ALPHA PRODUCTION Bionative AB (SE) 2001-10-10 EP claimed
EP-0743574-B1 Migration imaging members XEROX CORP (US) 2000-12-27 EP claimed
EP-0743573-B1 Method for obtaining image contrast migration imaging members XEROX CORP (US) 2000-09-06 EP claimed
WO-2000039163-A1 MODIFICATION OF INTERFERON ALPHA PRODUCTION BIONATIVE AB (SE) 2000-07-06 WO claimed
EP-0673783-B1 Recording sheets containing purine, pyrimidine, benzimidazole, imidazolidine, urazole, pyrazole, triazole, benzotriazole, tetrazole, and pyrazine compounds XEROX CORP (US) 2000-07-05 EP claimed
US-5659348-A APPLYING TO A SUBSTRATE XEROX CORPORATION (US) 1997-08-19 US claimed
EP-0743573-A2 Method for obtaining image contrast migration imaging members XEROX CORPORATION (US) 1996-11-20 EP claimed
EP-0743574-A2 Migration imaging members XEROX CORPORATION (US) 1996-11-20 EP claimed
US-5563014-A SOFTENABLE LAYER CONTAINIG PHOTOSENSITIVE MARKING MATERIAL; TRANSPARENTIZING AGENT XEROX CORPORATION (US) 1996-10-08 US claimed
US-5514505-A SELECTIVE TRANSPARENTIZATION OF PHOTOSENSITIVE MIGRATION MARKING PARTICLES EMBEDDED NEAR THE SURFACE OF A SOFTENABLE LAYER SUPPORTED BY AN ELECTROCONDUCTIVE SUBSTRATE XEROX CORPORATION (US) 1996-05-07 US claimed
EP-0673783-A2 Recording sheets containing purine, pyrimidine, benzimidazole, imidazolidine, urazole, pyrazole, triazole, benzotriazole, tetrazole, and pyrazine compounds XEROX CORPORATION (US) 1995-09-27 EP claimed
US-3932617-A AMINOHALOALKYLPYRIMIDINOLS THE UPJOHN COMPANY (US) 1976-01-13 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150011488-A1 ANTIVIRAL EPICATECHINS, EPICATECHIN OLIGOMERS, OR THIOLATED EPICATECHINS FROM THEOBROMA CACAO FOR TREATMENT OF GENITAL WARTS CUTA, OGG1, HAAO LMNA 1691/4885TLR8 127/4885ALDH1A1 1440/4885
US-20170035726-A1 ANTIVIRAL EPICATECHINS, EPICATECHIN OLIGOMERS, OR THIOLATED EPICATECHINS FROM THEOBROMA CACAO FOR TREATMENT OF GENITAL WARTS CUTA, OGG1, HAAO LMNA 1691/4885TLR8 127/4885ALDH1A1 1440/4885
US-20110218241-A1 ANTIVIRAL EPICATECHINS, EPICATECHIN OLIGOMERS, OR THIOLATED EPICATECHINS FROM THEOBROMA CACAO FOR TREATMENT OF GENITAL WARTS CUTA, OGG1, MGMT LMNA 1543/4885TLR8 192/4885ALDH1A1 1234/4885
US-20190142792-A1 ANTIVIRAL EPICATECHINS, EPICATECHIN OLIGOMERS, OR THIOLATED EPICATECHINS FROM THEOBROMA CACAO FOR TREATMENT OF GENITAL WARTS CUTA, OGG1, HAAO LMNA 1691/4885TLR8 127/4885ALDH1A1 1440/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.