Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.45 |
| ▸ | HRH1 | P35367 | 3/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.44 |
| ▸ | DTYMK | P23919 | 2/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.43 |
| ▸ | PRKCB | P05771 | 1/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | PRKCH | P24723 | 1/20 | 0.43 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23914636 | 0.88 | SMN1; SMN2 (0.50) | LMNASMN1; SMN2NPC1NR2F2HTT | |
| SCHEMBL23914934 | 0.86 | LMNA (0.51) | LMNASMN1; SMN2NPC1NR2F2HTT | |
| SCHEMBL2995095 | 0.84 | ADRA1A (0.69) | LMNASMN1; SMN2ADRA1AHRH1ADRA1B | |
| SCHEMBL23909121 | 0.82 | NPC1 (0.47) | LMNASMN1; SMN2NPC1NR2F2HTT | |
| SCHEMBL2820393 | 0.81 | ADRA1A (0.68) | LMNASMN1; SMN2ADRA1AHRH1ADRA1B | |
| SCHEMBL23908931 | 0.81 | NPC1 (0.47) | LMNASMN1; SMN2NPC1NR2F2HTT | |
| SCHEMBL23914926 | 0.77 | MAPT (0.48) | LMNASMN1; SMN2NPC1NR2F2HTT | |
| SCHEMBL26981264 | 0.77 | TP53 (0.39) | GPR119TP53STS | |
| SCHEMBL14636611 | 0.77 | GPR119 (0.53) | LMNAGPR119DTYMKPRKCGPRKCB | |
| SCHEMBL1990506 | 0.76 | CHRM2 (0.47) | LMNASMN1; SMN2NPC1NR2F2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649119-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2021-11-03 | — | — | EP | disclosed |