Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 14/20 | 0.69 |
| ▸ | HRH1 | P35367 | 14/20 | 0.69 |
| ▸ | ADRA1B | P35368 | 14/20 | 0.69 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.65 |
| ▸ | HTR2A | P28223 | 2/20 | 0.65 |
| ▸ | DRD3 | P35462 | 2/20 | 0.65 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.65 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.65 |
| ▸ | HTR2C | P28335 | 1/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.65 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2820393 | 0.96 | ADRA1A (0.68) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL23914636 | 0.84 | SMN1; SMN2 (0.50) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL23966858 | 0.84 | LMNA (0.46) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL23914934 | 0.82 | LMNA (0.51) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL4662127 | 0.80 | HRH1 (0.63) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL10519376 | 0.80 | ADRA1A (0.70) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL10556688 | 0.79 | ADRA1A (0.57) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL13241544 | 0.79 | ADRA1A (0.74) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL13241513 | 0.79 | HRH1 (0.71) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL2990937 | 0.79 | ABCB1 (0.92) | ADRA1AHRH1ADRA1BHRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100184770-A1 | COMPOUNDS | GLAXO GROUP LIMITED | 2010-07-22 | — | — | US | disclosed |
| US-20100184770-A1 | COMPOUNDS | GLAXO GROUP LIMITED | 2010-07-22 | — | — | US | disclosed |
| US-20100184770-A1 | COMPOUNDS | GLAXO GROUP LIMITED | 2010-07-22 | — | — | US | disclosed |
| EP-2091538-B1 | 4-BENZYL-1(2H)-PHTHALAZINONES AS H1 RECEPTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2010-03-03 | — | — | EP | disclosed |
| EP-2091538-B1 | 4-BENZYL-1(2H)-PHTHALAZINONES AS H1 RECEPTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008074803-A2 | 4-BENZYL-L ( 2H) -PHTHALAZINONES AS H1 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184770-A1 | COMPOUNDS | CMA1, TSLP, IL5 | ADRA1A 592/4885HRH1 4/4885ADRA1B 464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.