SCHEMBL23966917

SCHEMBL23966917

O=C(Nc1cc(C2(C(F)(F)F)CC2)no1)Oc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FAAH O00519 9/20 0.46
TRPV1 Q8NER1 8/20 0.46
BRAF P15056 2/20 0.44
ALDH1A1 P00352 1/20 0.40
MAPT P10636 1/20 0.40
CYP1A2 P05177 1/20 0.40
NEK7 Q8TDX7 1/20 0.39
KCNJ6 P48051 2/20 0.39
KCNJ5 P48544 2/20 0.39
KCNJ3 P48549 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1012030 0.95 BRAF (0.49) FAAHTRPV1BRAFALDH1A1MAPT
SCHEMBL11966200 0.83 FAAH (0.43) FAAHTRPV1ALDH1A1MAPTCYP1A2
SCHEMBL1012949 0.81 BRAF (0.47) FAAHTRPV1BRAFALDH1A1MAPT
SCHEMBL23966628 0.81 FAAH (0.44) FAAHTRPV1ALDH1A1MAPTCYP1A2
SCHEMBL23966706 0.80 ALDH1A1 (0.41) FAAHTRPV1ALDH1A1MAPTCYP1A2
SCHEMBL1012016 0.79 EPHX2 (0.48) FAAHTRPV1BRAFALDH1A1MAPT
SCHEMBL29484498 0.78 NEK7 (0.43) BRAFNEK7KCNJ6KCNJ5KCNJ3
SCHEMBL1012827 0.78 MAPK14 (0.45) FAAHTRPV1BRAFALDH1A1MAPT
SCHEMBL23966924 0.77 BRAF (0.47) BRAFALDH1A1MAPTCYP1A2
SCHEMBL23966921 0.77 FAAH (0.47) FAAHTRPV1BRAFALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4662206-A1 GSPT1 DEGRADER COMPOUNDS Captor Therapeutics S.A. (PL) 2025-12-17 EP disclosed
WO-2025067411-A1 NEK7 INHIBITOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF 北京普祺医药科技股份有限公司 2025-04-03 WO disclosed
US-12091413-B2 Inhibitors of NEK7 kinase Halia Therapeutics, Inc. (US) 2024-09-17 US disclosed
WO-2024165577-A1 GSPT1 DEGRADER COMPOUNDS CAPTOR THERAPEUTICS S.A. (PL) 2024-08-15 WO disclosed
EP-4146348-B1 INHIBITORS OF NEK7 KINASE HALIA THERAPEUTICS INC (US) 2024-07-03 EP disclosed
US-20240158394-A1 NEK7 INHIBITORS Halia Therapeutics, Inc. 2024-05-16 US disclosed
WO-2024059200-A1 NEK7 INHIBITORS Halia Therapeutics, Inc. (US) 2024-03-21 WO disclosed
US-20230416259-A1 INHIBITORS OF NEK7 KINASE HALIA THERAPEUTICS INC (US) 2023-12-28 US disclosed
US-11713321-B2 Inhibitors of NEK7 kinase Halia Therapeutics, Inc. (US) 2023-08-01 US disclosed
US-11713321-B2 Inhibitors of NEK7 kinase Halia Therapeutics, Inc. (US) 2023-08-01 US disclosed
US-20230210853-A1 TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME Halia Therapeutics, Inc. 2023-07-06 US disclosed
US-20230203045-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. 2023-06-29 US disclosed
US-20230203045-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. 2023-06-29 US disclosed
EP-4161933-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. (US) 2023-04-12 EP disclosed
EP-4146348-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. (US) 2023-03-15 EP disclosed
US-20220064173-A1 INHIBITORS OF NEK7 KINASE HALIA THERAPEUTICS INC (US) 2022-03-03 US disclosed
WO-2021252488-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. (US) 2021-12-16 WO disclosed
WO-2021242505-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. (US) 2021-12-02 WO disclosed
US-20210355130-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. 2021-11-18 US disclosed
US-11161852-B1 Inhibitors of NEK7 kinase Halia Therapeutics, Inc. (US) 2021-11-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210355130-A1 INHIBITORS OF NEK7 KINASE NEK7, NEK1, NEK5 FAAH 4600/4885TRPV1 1671/4885BRAF 578/4885
US-20230203045-A1 INHIBITORS OF NEK7 KINASE NEK7, NEK1, NEK5 FAAH 4568/4885TRPV1 1714/4885BRAF 507/4885
US-11713321-B2 Inhibitors of NEK7 kinase NEK7, NEK1, NEK5 FAAH 4600/4885TRPV1 1671/4885BRAF 578/4885
US-12091413-B2 Inhibitors of NEK7 kinase NEK7, NEK1, NEK5 FAAH 4600/4885TRPV1 1671/4885BRAF 578/4885
US-20230210853-A1 TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME NEK7, NLRP3, NOD1 FAAH 3955/4885TRPV1 2610/4885BRAF 1615/4885
US-11161852-B1 Inhibitors of NEK7 kinase NEK7, NEK1, NEK5 FAAH 4600/4885TRPV1 1671/4885BRAF 578/4885
US-20240158394-A1 NEK7 INHIBITORS NEK7, NEK5, NEK1 FAAH 4688/4885TRPV1 1544/4885BRAF 2323/4885
US-20230416259-A1 INHIBITORS OF NEK7 KINASE NEK7, NEK1, NEK5 FAAH 4600/4885TRPV1 1671/4885BRAF 578/4885
US-20220064173-A1 INHIBITORS OF NEK7 KINASE NEK7, NEK1, NEK5 FAAH 4600/4885TRPV1 1671/4885BRAF 578/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.