SCHEMBL23966628

SCHEMBL23966628

CC1(c2cc(NC(=O)Oc3ccccc3)on2)CCC1

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
FAAH O00519 10/20 0.44
TRPV1 Q8NER1 8/20 0.42
CCNE1 P24864 1/20 0.41
CDK2 P24941 1/20 0.41
CDK5 Q00535 1/20 0.41
MAPT P10636 3/20 0.40
ALDH1A1 P00352 3/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
MEN1 O00255 1/20 0.40
LMNA P02545 1/20 0.40
TP53 P04637 1/20 0.40
GAA P10253 1/20 0.40
KMT2A Q03164 1/20 0.40
CYP1A2 P05177 1/20 0.40
IDO1 P14902 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11966200 0.95 FAAH (0.43) FAAHTRPV1CCNE1CDK2CDK5
SCHEMBL23966706 0.89 ALDH1A1 (0.41) FAAHTRPV1CCNE1CDK2CDK5
SCHEMBL1012030 0.84 BRAF (0.49) FAAHTRPV1MAPTALDH1A1CYP1A2
SCHEMBL23966917 0.81 FAAH (0.46) FAAHTRPV1MAPTALDH1A1CYP1A2
SCHEMBL30813460 0.81 FAAH (0.46) FAAHTRPV1CCNE1CDK2CDK5
SCHEMBL25793263 0.78 CNR2 (0.45) ALDH1A1SMN1; SMN2MEN1LMNAKMT2A
SCHEMBL1895964 0.77 ALDH1A1 (0.53) CCNE1CDK2CDK5MAPTALDH1A1
SCHEMBL5224012 0.76 RAB9A (0.48) FAAHCCNE1CDK2CDK5MAPT
SCHEMBL1013412 0.76 MAPT (0.60) MAPTALDH1A1SMN1; SMN2MEN1TP53
SCHEMBL14353268 0.75 MAPK13 (0.47) FAAHTRPV1CCNE1CDK2CDK5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12091413-B2 Inhibitors of NEK7 kinase Halia Therapeutics, Inc. (US) 2024-09-17 US disclosed
EP-4146348-B1 INHIBITORS OF NEK7 KINASE HALIA THERAPEUTICS INC (US) 2024-07-03 EP disclosed
US-20240158394-A1 NEK7 INHIBITORS Halia Therapeutics, Inc. 2024-05-16 US disclosed
WO-2024059200-A1 NEK7 INHIBITORS Halia Therapeutics, Inc. (US) 2024-03-21 WO disclosed
US-20230416259-A1 INHIBITORS OF NEK7 KINASE HALIA THERAPEUTICS INC (US) 2023-12-28 US disclosed
US-11713321-B2 Inhibitors of NEK7 kinase Halia Therapeutics, Inc. (US) 2023-08-01 US disclosed
US-11713321-B2 Inhibitors of NEK7 kinase Halia Therapeutics, Inc. (US) 2023-08-01 US disclosed
US-20230210853-A1 TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME Halia Therapeutics, Inc. 2023-07-06 US disclosed
US-20230210853-A1 TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME Halia Therapeutics, Inc. 2023-07-06 US disclosed
US-20230203045-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. 2023-06-29 US disclosed
US-20230203045-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. 2023-06-29 US disclosed
EP-4161933-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. (US) 2023-04-12 EP disclosed
EP-4146348-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. (US) 2023-03-15 EP disclosed
US-20220064173-A1 INHIBITORS OF NEK7 KINASE HALIA THERAPEUTICS INC (US) 2022-03-03 US disclosed
WO-2021252488-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. (US) 2021-12-16 WO disclosed
WO-2021242505-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. (US) 2021-12-02 WO disclosed
US-20210355130-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. 2021-11-18 US disclosed
US-11161852-B1 Inhibitors of NEK7 kinase Halia Therapeutics, Inc. (US) 2021-11-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210355130-A1 INHIBITORS OF NEK7 KINASE NEK7, NEK1, NEK5 FAAH 4600/4885TRPV1 1671/4885CCNE1 2132/4885
US-20230203045-A1 INHIBITORS OF NEK7 KINASE NEK7, NEK1, NEK5 FAAH 4568/4885TRPV1 1714/4885CCNE1 2405/4885
US-11713321-B2 Inhibitors of NEK7 kinase NEK7, NEK1, NEK5 FAAH 4600/4885TRPV1 1671/4885CCNE1 2132/4885
US-12091413-B2 Inhibitors of NEK7 kinase NEK7, NEK1, NEK5 FAAH 4600/4885TRPV1 1671/4885CCNE1 2132/4885
US-20230210853-A1 TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME NEK7, NLRP3, NOD1 FAAH 3955/4885TRPV1 2610/4885CCNE1 3951/4885
US-11161852-B1 Inhibitors of NEK7 kinase NEK7, NEK1, NEK5 FAAH 4600/4885TRPV1 1671/4885CCNE1 2132/4885
US-20240158394-A1 NEK7 INHIBITORS NEK7, NEK5, NEK1 FAAH 4688/4885TRPV1 1544/4885CCNE1 3563/4885
US-20230416259-A1 INHIBITORS OF NEK7 KINASE NEK7, NEK1, NEK5 FAAH 4600/4885TRPV1 1671/4885CCNE1 2132/4885
US-20220064173-A1 INHIBITORS OF NEK7 KINASE NEK7, NEK1, NEK5 FAAH 4600/4885TRPV1 1671/4885CCNE1 2132/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.