Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.31 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.30 |
| ▸ | MERTK | Q12866 | 1/20 | 0.30 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25468268 | 0.81 | CHRNA7 (0.32) | CHRNA7 | |
| SCHEMBL23969324 | 0.74 | PLK1 (0.40) | L3MBTL4L3MBTL3FLT3TYRO3MERTK | |
| SCHEMBL21171187 | 0.70 | MAOA (0.40) | CHRNA7JAK2JAK1JAK3 | |
| SCHEMBL22175858 | 0.69 | L3MBTL4 (0.38) | L3MBTL4L3MBTL3 | |
| SCHEMBL22175908 | 0.69 | SIGMAR1 (0.37) | L3MBTL4L3MBTL3 | |
| SCHEMBL22176523 | 0.69 | SIGMAR1 (0.37) | L3MBTL4L3MBTL3 | |
| SCHEMBL22175863 | 0.69 | SIGMAR1 (0.37) | L3MBTL4L3MBTL3 | |
| SCHEMBL23969437 | 0.68 | SIGMAR1 (0.33) | — | |
| SCHEMBL24640579 | 0.67 | IKBKB (0.36) | CHEK1JAK2JAK1JAK3 | |
| SCHEMBL21171078 | 0.67 | CCNB2 (0.34) | JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3903788-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | Taisho Pharmaceutical Co., Ltd. (JP) | 2021-11-03 | — | — | EP | disclosed |