Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 7/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.39 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.37 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.35 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.34 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.32 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22175908 | 0.81 | SIGMAR1 (0.37) | PLK1L3MBTL4L3MBTL3TDP1ALDH1A1 | |
| SCHEMBL22176523 | 0.81 | SIGMAR1 (0.37) | PLK1L3MBTL4L3MBTL3TDP1ALDH1A1 | |
| SCHEMBL22175863 | 0.81 | SIGMAR1 (0.37) | PLK1L3MBTL4L3MBTL3TDP1ALDH1A1 | |
| SCHEMBL22175858 | 0.79 | L3MBTL4 (0.38) | PLK1L3MBTL4L3MBTL3TDP1ALDH1A1 | |
| SCHEMBL21075951 | 0.79 | PKM (0.39) | PLK1HDAC6ALDH1A1L3MBTL1 | |
| SCHEMBL23969212 | 0.78 | SIGMAR1 (0.37) | PLK1L3MBTL4L3MBTL3TDP1ALDH1A1 | |
| SCHEMBL22176372 | 0.76 | L3MBTL4 (0.34) | L3MBTL4L3MBTL3TDP1ALDH1A1L3MBTL1 | |
| SCHEMBL23969239 | 0.74 | CHEK1 (0.32) | L3MBTL4L3MBTL3FLT3TYRO3MERTK | |
| SCHEMBL23969437 | 0.71 | SIGMAR1 (0.33) | L3MBTL1 | |
| SCHEMBL21337896 | 0.70 | PLK1 (0.41) | PLK1HDAC6CNR2KAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3903788-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | Taisho Pharmaceutical Co., Ltd. (JP) | 2021-11-03 | — | — | EP | disclosed |