Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22175863 | 0.77 | SIGMAR1 (0.37) | SIGMAR1L3MBTL1HPGDTSHRKDM4E | |
| SCHEMBL22175908 | 0.77 | SIGMAR1 (0.37) | SIGMAR1L3MBTL1HPGDTSHRKDM4E | |
| SCHEMBL22176523 | 0.77 | SIGMAR1 (0.37) | SIGMAR1L3MBTL1HPGDTSHRKDM4E | |
| SCHEMBL22175858 | 0.75 | L3MBTL4 (0.38) | SIGMAR1L3MBTL1HPGDNOS3NOS1 | |
| SCHEMBL23969212 | 0.74 | SIGMAR1 (0.37) | SIGMAR1L3MBTL1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL22176509 | 0.73 | L3MBTL1 (0.35) | SIGMAR1L3MBTL1POLBTSHRKDM4E | |
| SCHEMBL22175913 | 0.71 | TAAR1 (0.39) | SIGMAR1L3MBTL1POLBKDM4EGAA | |
| SCHEMBL23969324 | 0.71 | PLK1 (0.40) | L3MBTL1 | |
| SCHEMBL22175890 | 0.69 | SIGMAR1 (0.33) | SIGMAR1L3MBTL1 | |
| SCHEMBL22176312 | 0.69 | SIGMAR1 (0.47) | SIGMAR1L3MBTL1HPGDTSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3903788-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | Taisho Pharmaceutical Co., Ltd. (JP) | 2021-11-03 | — | — | EP | disclosed |