Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | MTHFD2 | P13995 | 8/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | CLPP | Q16740 | 3/20 | 0.38 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30284121 | 1.00 | TRPV1 (0.40) | TRPV1MTHFD2KDRCLPPFFAR2 | |
| SCHEMBL23972801 | 0.96 | MTHFD2 (0.41) | TRPV1MTHFD2KDRCLPPMAPT | |
| SCHEMBL30283851 | 0.96 | MTHFD2 (0.41) | TRPV1MTHFD2KDRCLPPMAPT | |
| SCHEMBL30283867 | 0.95 | FFAR2 (0.39) | TRPV1MTHFD2KDRCLPPFFAR2 | |
| SCHEMBL23972455 | 0.95 | FFAR2 (0.39) | TRPV1MTHFD2KDRCLPPFFAR2 | |
| SCHEMBL23972792 | 0.93 | TRPV1 (0.38) | TRPV1MTHFD2KDRCLPPMAPT | |
| SCHEMBL30283915 | 0.93 | TRPV1 (0.38) | TRPV1MTHFD2KDRCLPPMAPT | |
| SCHEMBL23972793 | 0.93 | TRPV1 (0.38) | TRPV1MTHFD2KDRCLPPFFAR2 | |
| SCHEMBL23973447 | 0.93 | GPR142 (0.39) | TRPV1MTHFD2KDRCLPPFFAR2 | |
| SCHEMBL30284337 | 0.93 | TRPV1 (0.38) | TRPV1MTHFD2KDRCLPPFFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230339934-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | RAQUALIA PHARMA INC. (JP) | 2023-10-26 | — | — | US | disclosed |
| US-20230339934-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | RAQUALIA PHARMA INC. (JP) | 2023-10-26 | — | — | US | disclosed |
| WO-2021221169-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | RAQUALIA PHARMA INC. (JP) | 2021-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230339934-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | TRPV4, TRPV1, TRPV2 | TRPV1 2/4885MTHFD2 2762/4885KDR 1910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.