Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 3/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.39 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23986840 | 0.82 | KDM4E (0.50) | KDM4EL3MBTL1ALOX15TDP1NPC1 | |
| SCHEMBL20665835 | 0.78 | METAP2 (0.53) | KDM4EL3MBTL1ALOX15TDP1HTT | |
| SCHEMBL10150242 | 0.77 | L3MBTL1 (0.50) | KDM4EL3MBTL1ALOX15TDP1NPC1 | |
| SCHEMBL23975633 | 0.76 | PDE4B (0.52) | KDM4ETDP1HTTTP53SMN1; SMN2 | |
| SCHEMBL23975644 | 0.76 | TDP1 (0.61) | KDM4EL3MBTL1ALOX15TDP1RAB9A | |
| SCHEMBL11036761 | 0.75 | KDM4E (0.68) | KDM4EL3MBTL1ALOX15TDP1NPC1 | |
| SCHEMBL10150244 | 0.74 | RAB9A (0.59) | L3MBTL1ALOX15TDP1RAB9APPP1CA | |
| SCHEMBL23975719 | 0.74 | PDE10A (0.44) | KDM4EL3MBTL1TDP1NPC1HTT | |
| SCHEMBL23976684 | 0.74 | KDM4E (0.42) | KDM4EL3MBTL1ALOX15TDP1NPC1 | |
| SCHEMBL23976131 | 0.74 | RAB9A (0.49) | L3MBTL1ALOX15TDP1RAB9APPP1CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |