Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20665835 | 0.84 | METAP2 (0.53) | TRPV1KMT2AMETAP1KDM4ETDP1 | |
| SCHEMBL30225366 | 0.79 | PDE4B (0.47) | PDE4BKMT2AMETAP1KDM4ETDP1 | |
| SCHEMBL23976252 | 0.79 | PDE4B (0.47) | PDE4BKMT2AMETAP1KDM4ETDP1 | |
| SCHEMBL30225282 | 0.79 | HIF1A (0.54) | KMT2AKDM4EHTTSMN1; SMN2HIF1A | |
| SCHEMBL23975681 | 0.79 | HIF1A (0.54) | KMT2AKDM4EHTTSMN1; SMN2HIF1A | |
| Hydrochloric Acid SCHEMBL30225354 | 0.77 | KMT2A (0.45) | PDE4BTRPV1KMT2AKDM4ETDP1 | |
| SCHEMBL23986840 | 0.76 | KDM4E (0.50) | KMT2AMETAP1KDM4ETDP1POLB | |
| SCHEMBL23975565 | 0.76 | KDM4E (0.51) | METAP1KDM4ETDP1POLBADORA3 | |
| SCHEMBL18997755 | 0.76 | MERTK (0.52) | KMT2AKDM4ETDP1HTTSMN1; SMN2 | |
| SCHEMBL20665834 | 0.75 | TRPM8 (0.41) | TRPV1KMT2AKDM4ETDP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4142732-B1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS INC (US) | 2026-04-22 | — | — | EP | disclosed |
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |