Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.70 |
| ▸ | NPC1 | O15118 | 10/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.70 |
| ▸ | MAPT | P10636 | 6/20 | 0.65 |
| ▸ | GBA1 | P04062 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16383911 | 0.82 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2MAPTGBA1 | |
| SCHEMBL27581139 | 0.82 | RAB9A (0.73) | RAB9ANPC1SMN1; SMN2MAPTGBA1 | |
| SCHEMBL23977677 | 0.81 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2MAPTGBA1 | |
| SCHEMBL4123004 | 0.80 | RAB9A (0.70) | RAB9ANPC1SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL27568918 | 0.79 | RAB9A (0.68) | RAB9ANPC1SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL27578747 | 0.79 | RAB9A (0.68) | RAB9ANPC1SMN1; SMN2MAPTGBA1 | |
| SCHEMBL24008310 | 0.78 | NPC1 (0.69) | RAB9ANPC1SMN1; SMN2MAPTGBA1 | |
| SCHEMBL27578807 | 0.78 | RAB9A (0.74) | RAB9ANPC1SMN1; SMN2MAPTGBA1 | |
| SCHEMBL23977676 | 0.78 | RAB9A (0.58) | RAB9ANPC1SMN1; SMN2MAPTGBA1 | |
| SCHEMBL27596647 | 0.77 | RAB9A (0.65) | RAB9ANPC1SMN1; SMN2MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219893-A1 | Krüppel-Like Factor 15 (KLF15) Small Molecule Agonists in Kidney Disease | US GOV VETERANS AFFAIRS (US) | 2023-07-13 | — | — | US | disclosed |
| US-20230219893-A1 | Krüppel-Like Factor 15 (KLF15) Small Molecule Agonists in Kidney Disease | US GOV VETERANS AFFAIRS (US) | 2023-07-13 | — | — | US | disclosed |
| US-11643394-B2 | Krüppel-like factor 15 (KLF15) small molecule agonists in kidney disease | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-05-09 | — | — | US | disclosed |
| US-11643394-B2 | Krüppel-like factor 15 (KLF15) small molecule agonists in kidney disease | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-05-09 | — | — | US | disclosed |
| US-20210347734-A1 | Krüppel-Like Factor 15 (KLF15) Small Molecule Agonists in Kidney Disease | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK | 2021-11-11 | — | — | US | disclosed |
| WO-2021222637-A1 | KRÜPPEL-LIKE FACTOR 15 (KLF15) SMALL MOLECULE AGONISTS IN KIDNEY DISEASE | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (US) | 2021-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11643394-B2 | Krüppel-like factor 15 (KLF15) small molecule agonists in kidney disease | KIF15, KLF5, KLF10 | RAB9A 1697/4885NPC1 834/4885SMN1; SMN2 45/4885 |
| US-20230219893-A1 | Krüppel-Like Factor 15 (KLF15) Small Molecule Agonists in Kidney Disease | KIF15, KLF5, KLF10 | RAB9A 1697/4885NPC1 834/4885SMN1; SMN2 45/4885 |
| US-20210347734-A1 | Krüppel-Like Factor 15 (KLF15) Small Molecule Agonists in Kidney Disease | KIF15, KLF5, KLF10 | RAB9A 1697/4885NPC1 834/4885SMN1; SMN2 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.