Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.82 |
| ▸ | TP53 | P04637 | 1/20 | 0.82 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.82 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.82 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.47 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.42 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL344296 | 1.00 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL2397933 | 1.00 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL344295 | 1.00 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL3777151 | 1.00 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL16234752 | 1.00 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL28510554 | 0.96 | TSHR (0.75) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL21145325 | 0.96 | TSHR (0.75) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL21145327 | 0.96 | TSHR (0.75) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL27799964 | 0.96 | TSHR (0.75) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL27770053 | 0.96 | TSHR (0.75) | TSHRTP53EGLN1EGLN3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111471485-B | Method for removing sodium salt from hydrocarbon oil | 中国石油化工股份有限公司 | 2021-12-17 | — | — | CN | claimed |
| CN-111471485-A | Method for removing sodium salt from hydrocarbon oil | 中国石油化工股份有限公司 | 2020-07-31 | — | — | CN | claimed |
| WO-2014183656-A1 | SEPARATOR AND METHOD FOR PREPARING THE SAME | SHENZHEN BYD AUTO R&D COMPANY LIMITED (CN) | 2014-11-20 | — | — | WO | claimed |
| CN-102952566-B | Dehydration method of oilfield produced fluid | CHINA PETROLEUM & CHEMICAL | 2014-12-31 | — | — | CN | disclosed |
| WO-2014183656-A1 | SEPARATOR AND METHOD FOR PREPARING THE SAME | SHENZHEN BYD AUTO R&D COMPANY LIMITED (CN) | 2014-11-20 | — | — | WO | disclosed |
| US-8476369-B2 | Metal salt nanogel-containing polymers | BAYER INNOVATION GMBH (DE) | 2013-07-02 | — | — | US | disclosed |
| CN-102952566-A | Dehydration method of oilfield produced fluid | CHINA PETROLEUM & CHEMICAL | 2013-03-06 | — | — | CN | disclosed |
| US-8022155-B2 | Polymerized molded body | TECHNISCHE UNIVERSITAT WIEN (AT) | 2011-09-20 | — | — | US | disclosed |
| US-20100178270-A1 | METAL SALT NANOGEL-CONTAINING POLYMERS | HELLING INNOVATION UG | 2010-07-15 | — | — | US | disclosed |
| US-20080287565-A1 | Polymerized Molded Body | TECHNISCHE UNIVERSITAT WIEN (AT) | 2008-11-20 | — | — | US | disclosed |
| WO-2008043853-A2 | PHOTOCHROMIC FILM | OPCO GMBH (DE) | 2008-04-17 | — | — | WO | disclosed |
| US-6313196-B1 | FOR INK JET PRINTING; SMUDGE RESISTANCE | AGFA-GEVAERT (BE) | 2001-11-06 | — | — | US | disclosed |
| EP-0247457-B1 | PROCESS FOR THE PREPARATION OF REAGENT LAYERS CONTAINING HYDROPHOBIC REAGENTS | MILES INC. (US) | 1993-04-07 | — | — | EP | disclosed |
| US-5126479-A | Wire lacquers | BAYER AKTIENGESELLSCHAFT (DE) | 1992-06-30 | — | — | US | disclosed |
| US-5063128-A | Forming a semitransparent conductive layer of particles having acidic surfaces and a polymer; xerography; humidity resistance; durability | XEROX CORPORATION (US) | 1991-11-05 | — | — | US | disclosed |
| US-5057276-A | Dissolving ionomeric polymer and reagent in solvent, adding water, and removing solvent | MILES INC. (US) | 1991-10-15 | — | — | US | disclosed |
| US-4935535-A | Noncatalytic reaction | NATIONAL SCIENCE COUNCIL (TW) | 1990-06-19 | — | — | US | disclosed |
| EP-0247457-A2 | Process for the preparation of reagent layers containing hydrophobic reagents | MILES INC. (US) | 1987-12-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100178270-A1 | METAL SALT NANOGEL-CONTAINING POLYMERS | PUF60, WASHC5, SLC39A3 | KMT2A 3534/4885MEN1 2316/4885TSHR 4678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.