Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.75 |
| ▸ | TP53 | P04637 | 1/20 | 0.75 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.75 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.45 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.40 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL21145325 | 1.00 | TSHR (0.75) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL27799964 | 1.00 | TSHR (0.75) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL2397939 | 0.96 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL344295 | 0.96 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL16234752 | 0.96 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL2397933 | 0.96 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL344296 | 0.96 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL3777151 | 0.96 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL28510554 | 0.92 | TSHR (0.75) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL28199753 | 0.92 | TSHR (0.75) | TSHRTP53EGLN1EGLN3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200179254-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2020-06-11 | — | — | US | disclosed |
| US-20190240129-A1 | CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2019-08-08 | — | — | US | disclosed |
| US-20190216714-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2019-07-18 | — | — | US | disclosed |
| US-20190216703-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2019-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190240129-A1 | CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, CUTA, S100A10 | KMT2A 242/4885MEN1 3369/4885TSHR 3146/4885 |
| US-20190216703-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, SRRM2, IK | KMT2A 912/4885MEN1 4505/4885TSHR 1850/4885 |
| US-20190216714-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, CD44, PCNA | KMT2A 97/4885MEN1 2001/4885TSHR 3345/4885 |
| US-20200179254-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, CUTA, DSG1 | KMT2A 59/4885MEN1 3038/4885TSHR 2235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.