Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CA1 | P00915 | 4/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | AGXT | P21549 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA9 | Q16790 | 3/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8570929 | 0.78 | TSHR (0.61) | TSHRKDM4EPOLBALDH1A1CA1 | |
| SCHEMBL8743531 | 0.78 | TSHR (0.50) | TSHRKDM4EPOLBALDH1A1CA1 | |
| SCHEMBL4889465 | 0.78 | TSHR (0.50) | TSHRKDM4EPOLBALDH1A1CA1 | |
| SCHEMBL18526730 | 0.75 | KDM4E (0.53) | TSHRKDM4EPOLBALDH1A1CA1 | |
| SCHEMBL9521927 | 0.75 | TSHR (0.47) | TSHRKDM4EPOLBALDH1A1CA1 | |
| SCHEMBL2398268 | 0.74 | SMN1; SMN2 (0.42) | ALDH1A1MAOBSMN1; SMN2 | |
| SCHEMBL9521935 | 0.74 | TSHR (0.45) | TSHRKDM4EPOLBALDH1A1CA1 | |
| SCHEMBL11146323 | 0.73 | TSHR (0.67) | TSHRKDM4EPOLBALDH1A1CA1 | |
| SCHEMBL13888734 | 0.73 | KDM4E (0.46) | TSHRKDM4EPOLBALDH1A1CA1 | |
| SCHEMBL20267477 | 0.71 | TSHR (0.47) | TSHRKDM4EPOLBALDH1A1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130274470-A1 | Triazolium Carbene Catalysts and Stereoselective Bond Forming Reactions Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-10-17 | — | — | US | disclosed |
| US-20110224431-A1 | Triazolium Carbene Catalysts and Stereoselective Bond Forming Reactions Thereof | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274470-A1 | Triazolium Carbene Catalysts and Stereoselective Bond Forming Reactions Thereof | HDHD5, DCX, CLK2 | TSHR 1020/4885KDM4E 4494/4885POLB 996/4885 |
| US-20110224431-A1 | Triazolium Carbene Catalysts and Stereoselective Bond Forming Reactions Thereof | HDHD5, DCX, CLK2 | TSHR 1020/4885KDM4E 4494/4885POLB 996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.