Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | ATP4A | P20648 | 3/20 | 0.46 |
| ▸ | ATP4B | P51164 | 3/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.45 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24393199 | 0.87 | SLC6A3 (0.41) | HPGDSSLC6A3ATP4AATP4BSRC | |
| SCHEMBL6381401 | 0.84 | HPGDS (0.54) | HPGDSSLC6A3SRCIMPDH2IMPDH1 | |
| SCHEMBL16132474 | 0.82 | CCR1 (0.57) | HPGDSATP4AATP4BHTR1AADRA1D | |
| SCHEMBL24392645 | 0.81 | HPGDS (0.51) | HPGDSSLC6A3SRCIMPDH2IMPDH1 | |
| SCHEMBL24391743 | 0.81 | HPGDS (0.51) | HPGDSSLC6A3ATP4AATP4BSRC | |
| SCHEMBL24715854 | 0.78 | HTR1A (0.55) | HPGDSSLC6A3IMPDH2IMPDH1HTR1A | |
| SCHEMBL6381081 | 0.75 | EGFR (0.56) | SRCEGFRERBB2 | |
| SCHEMBL5256736 | 0.74 | IMPDH2 (0.48) | HPGDSSLC6A3SRCIMPDH2IMPDH1 | |
| SCHEMBL16132482 | 0.74 | CCR1 (0.55) | — | |
| SCHEMBL6382190 | 0.73 | EGFR (0.54) | HPGDSSLC6A3SRCEGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022091048-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE-1 (ENPP1) INHIBITORS AND USES THEREOF | INTEGRAL BIOSCIENCES PRIVATE LIMITED (IN) | 2022-05-05 | — | — | WO | disclosed |
| WO-2021225969-A1 | IMINO SULFANONE INHIBITORS OF ENPP1 | VOLASTRA THERAPEUTICS, INC. (US) | 2021-11-11 | — | — | WO | disclosed |