Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.42 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 2/20 | 0.40 |
| ▸ | LITAF | Q99732 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24009148 | 0.81 | HPGDS (0.55) | HPGDSSLC6A3HTR1AADRA1DADRA1A | |
| SCHEMBL6381401 | 0.80 | HPGDS (0.54) | HPGDSSLC6A3KDM4EHTR1AADRA1D | |
| SCHEMBL24391743 | 0.78 | HPGDS (0.51) | HPGDSSLC6A3HTR1AADRA1DADRA1A | |
| SCHEMBL24715854 | 0.75 | HTR1A (0.55) | HPGDSSLC6A3KDM4EHTR1AADRA1D | |
| SCHEMBL24392117 | 0.74 | SRC (0.56) | SRC | |
| SCHEMBL16884618 | 0.74 | POLB (0.46) | KDM4ETSHRNPSR1IMPDH2IMPDH1 | |
| SCHEMBL4572184 | 0.73 | LRRK2 (0.54) | KDM4EIMPDH2SRCMEN1KMT2A | |
| SCHEMBL24393332 | 0.73 | SLC6A3 (0.58) | HPGDSSLC6A3KDM4ENPSR1MEN1 | |
| SCHEMBL24009068 | 0.72 | EGFR (0.41) | HPGDSSLC6A3 | |
| SCHEMBL24009065 | 0.72 | ALDH1A1 (0.43) | HPGDSSLC6A3KDM4ESRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220135598-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE-1 (ENPP1) INHIBITORS AND USES THEREOF | INTEGRAL BIOSCIENCES PRIVATE LIMITED (IN) | 2022-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220135598-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE-1 (ENPP1) INHIBITORS AND USES THEREOF | ENPP1, ENPP3, ENPP2 | HPGDS 420/4885SLC6A3 2660/4885KDM4E 3129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.