Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.53 |
| ▸ | STS | P08842 | 10/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.49 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | PGR | P06401 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8638232 | 0.83 | STS (0.51) | ESR1ESR2STSNR3C1NR3C2 | |
| SCHEMBL8145976 | 0.79 | ESR1 (0.55) | ESR1ESR2STSNR3C1NR3C2 | |
| SCHEMBL8145253 | 0.79 | ESR1 (0.55) | ESR1ESR2STSNR3C1NR3C2 | |
| SCHEMBL2399541 | 0.78 | HSD17B1 (0.66) | ESR1ESR2STSLMNAPGR | |
| SCHEMBL22181611 | 0.78 | STS (0.71) | ESR1ESR2STSNR3C1NR3C2 | |
| SCHEMBL9603296 | 0.78 | ESR1 (0.56) | ESR1ESR2STSNR3C1NR3C2 | |
| SCHEMBL10631994 | 0.77 | ESR1 (0.63) | ESR1ESR2STSNR3C1LMNA | |
| SCHEMBL10599506 | 0.77 | ESR1 (0.63) | ESR1ESR2STSNR3C1LMNA | |
| SCHEMBL5983440 | 0.75 | ESR1 (0.56) | ESR1ESR2STSNR3C1NR3C2 | |
| SCHEMBL2677733 | 0.75 | ESR1 (0.56) | ESR1ESR2STSNR3C1NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111409-B1 | NOVEL CATIONIC 17 ALPHA- SUBSTITUTED-ESTRADIOL DERIVATIVES USEFUL AS ANTI-CANCER AGENT | COUNCIL SCIENT IND RES (IN) | 2012-06-27 | — | — | EP | disclosed |
| US-8012952-B2 | Cationic 17 α-substituted-estradiol derivatives useful as anti-cancer agent | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2011-09-06 | — | — | US | disclosed |
| EP-2111409-A1 | NOVEL CATIONIC 17 ALPHA- SUBSTITUTED-ESTRADIOL DERIVATIVES USEFUL AS ANTI-CANCER AGENT | Council of Scientific&Industrial Research (IN) | 2009-10-28 | — | — | EP | disclosed |
| US-20090062230-A1 | NOVEL CATIONIC 17 ALPHA-SUBSTITUTED-ESTRADIOL DERIVATIVES USEFUL AS ANTI-CANCER AGENT | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2009-03-05 | — | — | US | disclosed |
| WO-2008099414-A1 | NOVEL CATIONIC 17 α- SUBSTITUTED-ESTRADIOL DERIVATIVES USEFUL AS ANTI-CANCER AGENT | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2008-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062230-A1 | NOVEL CATIONIC 17 ALPHA-SUBSTITUTED-ESTRADIOL DERIVATIVES USEFUL AS ANTI-CANCER AGENT | ESR2, ESR1, GPER1 | ESR1 2/4885ESR2 1/4885STS 2580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.