Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | KCNN2 | Q9H2S1 | 2/20 | 0.35 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9132704 | 0.79 | CALM1 (0.35) | CALM1CNR2GPR55TAAR1SIGMAR1 | |
| SCHEMBL27923091 | 0.77 | GABRA1 (0.38) | TAAR1SIGMAR1GABRA1GABRB2SLC6A2 | |
| SCHEMBL7422922 | 0.77 | GABRA1 (0.38) | GABRA1GABRB2SLC6A2GABRG2GABRB3 | |
| SCHEMBL6015438 | 0.76 | GABRA1 (0.36) | GABRA1GABRB2SLC6A2GABRG2GABRB3 | |
| SCHEMBL7453243 | 0.76 | CALM1 (0.42) | CALM1ALDH1A1IDH1CYP2D6LTA4H | |
| SCHEMBL28054360 | 0.76 | GABRA1 (0.50) | SIGMAR1GABRA1GABRB2SLC6A2GABRG2 | |
| SCHEMBL28235589 | 0.75 | CNR2 (0.41) | CALM1CNR2GPR55TAAR1SIGMAR1 | |
| SCHEMBL8939699 | 0.75 | ADRA1D (0.39) | CALM1TAAR1SIGMAR1SLC18A2MAOA | |
| SCHEMBL8466360 | 0.74 | CALM1 (0.55) | CALM1TAAR1ALDH1A1IDH1LTA4H | |
| SCHEMBL721135 | 0.73 | CALM1 (0.44) | CALM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4778954-B2 | — | — | 2011-09-21 | — | — | JP | claimed |
| JP-2007529527-A | — | — | 2007-10-25 | — | — | JP | claimed |
| EP-1725537-A1 | NOVEL COMPOUNDS AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-11-29 | — | — | EP | claimed |
| WO-2005090315-A1 | NOVEL COMPOUNDS AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N. V. (BE) | 2005-09-29 | — | — | WO | claimed |
| EP-1725537-A1 | NOVEL COMPOUNDS AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005090315-A1 | NOVEL COMPOUNDS AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N. V. (BE) | 2005-09-29 | — | — | WO | disclosed |