Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8939752 | 0.83 | ADRA1D (0.42) | ADRA1DADRA1AADRA1BMAOASIGMAR1 | |
| SCHEMBL8859963 | 0.81 | LTA4H (0.44) | ADRA1DADRA1AADRA1BHTR1ACALM1 | |
| SCHEMBL16954285 | 0.80 | IRAK4 (0.36) | ADRA1DADRA1AADRA1BKDM4ELMNA | |
| SCHEMBL8939785 | 0.79 | HTR1A (0.42) | ADRA1DADRA1AADRA1BKDM4EALDH1A1 | |
| SCHEMBL8939743 | 0.77 | MAPT (0.49) | ADRA1DADRA1AADRA1BTDP1HTR1A | |
| SCHEMBL8939792 | 0.75 | CYP1A2 (0.46) | LMNATSHR | |
| SCHEMBL2401466 | 0.75 | CALM1 (0.38) | ALDH1A1MAOACALM1TAAR1SLC18A2 | |
| SCHEMBL8939734 | 0.72 | HPGD (0.41) | ADRA1AKDM4ELMNAALDH1A1HTR1A | |
| SCHEMBL7453243 | 0.72 | CALM1 (0.42) | KDM4ELMNATDP1ALDH1A1ACHE | |
| SCHEMBL7701983 | 0.71 | IRAK4 (0.42) | ADRA1DADRA1AADRA1BKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516797-A | SUPPRESSING GRAFT REJECTION | VERTEX PHARMACEUTICALS, INCORPORATED (US) | 1996-05-14 | — | — | US | disclosed |
| US-5330993-A | Immunosuppressive compounds | VERTEX PHARMACEUTICALS, INC. (US) | 1994-07-19 | — | — | US | disclosed |