Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.56 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.56 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GCK | P35557 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27144888 | 0.87 | DAO (0.48) | MTNR1AMTNR1BDAOATAD2HRH4 | |
| SCHEMBL25587553 | 0.85 | DAO (0.43) | MTNR1AMTNR1BDAOATAD2HRH4 | |
| SCHEMBL29865238 | 0.83 | ATAD2 (0.49) | MTNR1AMTNR1BDAOATAD2HRH4 | |
| SCHEMBL30759248 | 0.82 | BCHE (0.49) | MTNR1AMTNR1BDAOATAD2PRMT5 | |
| SCHEMBL18361821 | 0.78 | RIPK1 (0.48) | MTNR1AMTNR1BDAOHRH4L3MBTL1 | |
| SCHEMBL3429551 | 0.76 | DAO (0.51) | DAOATAD2HRH4PRMT5WDR77 | |
| SCHEMBL13415981 | 0.76 | MTNR1A (0.73) | MTNR1AMTNR1BKDM4EALDH1A1MAPT | |
| SCHEMBL12677225 | 0.75 | ATAD2 (0.53) | DAOATAD2HRH4CNR2NPSR1 | |
| SCHEMBL30040118 | 0.75 | DAO (0.53) | DAOATAD2HRH4PRMT5WDR77 | |
| SCHEMBL9396748 | 0.75 | DAO (0.53) | DAOATAD2HRH4PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023072974-A1 | TRICYCLIC HETEROCYCLES | MERCK PATENT GMBH (DE) | 2023-05-04 | — | — | WO | disclosed |
| WO-2021224291-A1 | TRICYCLIC HETEROCYCLES USEFUL AS TEAD BINDERS | MERCK PATENT GMBH (DE) | 2021-11-11 | — | — | WO | disclosed |