SCHEMBL2402302

SCHEMBL2402302

OC1C=Cc2ccccc2N1O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
LMNA P02545 3/20 0.40
SMN1; SMN2 Q16637 3/20 0.40
TSHR P16473 2/20 0.38
MAPK1 P28482 2/20 0.38
SCN4A P35499 1/20 0.38
SCN5A Q14524 1/20 0.38
SCN9A Q15858 1/20 0.38
P2RX4 Q99571 11/20 0.38
P2RX1 P51575 6/20 0.38
P2RX3 P56373 6/20 0.38
P2RX7 Q99572 3/20 0.38
ALDH1A1 P00352 3/20 0.36
NPSR1 Q6W5P4 2/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
IDH1 O75874 1/20 0.36
USP2 O75604 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31558693 1.00 MEN1 (0.40) MEN1KMT2ALMNASMN1; SMN2TSHR
SCHEMBL3253414 0.78 MEN1 (0.42) MEN1KMT2ALMNASMN1; SMN2TSHR
SCHEMBL28017429 0.78 MEN1 (0.39) MEN1KMT2ALMNASMN1; SMN2TSHR
SCHEMBL28016737 0.78 KMT2A (0.39) MEN1KMT2ALMNASMN1; SMN2TSHR
SCHEMBL27594996 0.75 SMN1; SMN2 (0.49) MEN1KMT2ALMNASMN1; SMN2MAPK1
SCHEMBL5527248 0.73 ALDH1A1 (0.42) MEN1KMT2ALMNASMN1; SMN2TSHR
SCHEMBL28886571 0.73 SMN1; SMN2 (0.42) MEN1KMT2ALMNASMN1; SMN2TSHR
SCHEMBL935561 0.73 LMNA (0.37) MEN1KMT2ALMNASMN1; SMN2TSHR
SCHEMBL11792980 0.73 SMN1; SMN2 (0.46) MEN1KMT2ALMNASMN1; SMN2TSHR
SCHEMBL11197612 0.73 MEN1 (0.54) MEN1KMT2ALMNASMN1; SMN2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109563432-A Grease composition 协同油脂株式会社 2019-04-02 CN claimed
EP-2352876-B1 TREATED TEXTILE MATERIAL FOR USE IN AQUATIC ENVIRONMENTS BASF SE (DE) 2012-12-12 EP claimed
US-20110217348-A1 TREATED TEXTILE MATERIAL FOR USE IN AQUATIC ENVIRONMENTS BASF SE (DE) 2011-09-08 US claimed
US-20030162809-A1 Use of dihydroxyquinoline to aid in increasing milk production and feed utilization SOLUTIA, INC. (US) 2003-08-28 US claimed
EP-0998193-B1 USE OF DIHYDROXYQUINOLINE COMPOUNDS TO EXTEND THE SHELF LIFE OF PRODUCTS OF MAMMALS AND FISH SOLUTIA INC (US) 2003-01-29 EP claimed
CN-109563432-A Grease composition 协同油脂株式会社 2019-04-02 CN disclosed
EP-2352876-B1 TREATED TEXTILE MATERIAL FOR USE IN AQUATIC ENVIRONMENTS BASF SE (DE) 2012-12-12 EP disclosed
US-20110217348-A1 TREATED TEXTILE MATERIAL FOR USE IN AQUATIC ENVIRONMENTS BASF SE (DE) 2011-09-08 US disclosed
CN-100532392-C Reductive alkylation process ADVANCED MEDICINE INC (US) 2009-08-26 CN disclosed
CN-100469788-C Glycopeptide phosphonate derivatives ADVANCED MEDICINE INC (US) 2009-03-18 CN disclosed
CN-100418980-C Method for purifying glycopeptide phosphonate derivatives THERAVANCE INC (US) 2008-09-17 CN disclosed
JP-2008143891-A NEW 1,2-DIHYDROXYQUINOLINE DERIVATIVE HAVING (SUBSTITUTED PHENYL OR SUBSTITUTED HETEROCYCLIC)CARBONYLOXY LOWER ALKYL GROUP AND ESTER STRUCTURE-INTRODUCED PHENYL GROUP AS SUBSTITUENT SANTEN PHARMACEUT CO LTD 2008-06-26 JP disclosed
EP-0998193-B1 USE OF DIHYDROXYQUINOLINE COMPOUNDS TO EXTEND THE SHELF LIFE OF PRODUCTS OF MAMMALS AND FISH SOLUTIA INC (US) 2003-01-29 EP disclosed
CN-1315961-A Glycopeptide derivatives and pharmaceutical compositions containing same ADVANCED MEDICINE INC (US) 2001-10-03 CN disclosed
EP-0998193-A4 USE OF DIHYDROXYQUINOLINE COMPOUNDS TO EXTEND THE SHELF LIFE OF PRODUCTS OF MAMMALS AND FISH SOLUTIA INC (US) 2000-05-31 EP disclosed
EP-0998193-A1 USE OF DIHYDROXYQUINOLINE COMPOUNDS TO EXTEND THE SHELF LIFE OF PRODUCTS OF MAMMALS AND FISH Solutia Inc. (US) 2000-05-10 EP disclosed
WO-1999016441-A1 APORPHINOID MATRIX METALLOPROTEINASE INHIBITORS ROCHE DIAGNOSTICS GMBH (DE) 1999-04-08 WO disclosed
WO-1999004624-A1 USE OF DIHYDROXYQUINOLINE COMPOUNDS TO EXTEND THE SHELF LIFE OF PRODUCTS OF MAMMALS AND FISH SOLUTIA INC. (US) 1999-02-04 WO disclosed
EP-0752872-A1 NADH OXIDASE AS A TARGET IN DIAGNOSIS AND THERAPY Portola Sciences, Inc. (US) 1997-01-15 EP disclosed
WO-1995026743-A1 NADH OXIDASE AS A TARGET IN DIAGNOSIS AND THERAPY PORTOLA SCIENCES, INC. (US) 1995-10-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030162809-A1 Use of dihydroxyquinoline to aid in increasing milk production and feed utilization NDUFB5, NQO2, DBH MEN1 4061/4885KMT2A 939/4885LMNA 3770/4885
US-20110217348-A1 TREATED TEXTILE MATERIAL FOR USE IN AQUATIC ENVIRONMENTS C9, ADORA2B, C5 MEN1 890/4885KMT2A 2066/4885LMNA 754/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.