Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NR2E1 | Q9Y466 | 3/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | PREP | P48147 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2404534 | 0.96 | NR2E1 (0.41) | NR2E1NSD2TACR3MEN1NPC1 | |
| Trifluoroacetic Acid SCHEMBL28146694 | 0.78 | L3MBTL1 (0.64) | L3MBTL1NR2E1NSD2KMT2ACYP1A2 | |
| SCHEMBL27279918 | 0.74 | MAPK1 (0.46) | L3MBTL1NR2E1NSD2MAPK1CYP1A2 | |
| SCHEMBL17927686 | 0.74 | RAB9A (0.54) | NR2E1NSD2TACR3MEN1NPC1 | |
| SCHEMBL3054110 | 0.72 | PDK1 (0.56) | NSD2NPC1GAARAB9AALDH1A1 | |
| Quinolin-4-Amine SCHEMBL27598920 | 0.72 | NCF1 (0.68) | L3MBTL1MEN1NPC1MAPTRAB9A | |
| Quinolin-4-Amine SCHEMBL8908513 | 0.72 | NCF1 (0.68) | L3MBTL1MEN1NPC1MAPTRAB9A | |
| Trifluoroacetic Acid SCHEMBL28101328 | 0.72 | SMN1; SMN2 (0.44) | L3MBTL1NR2E1CYP1A2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8568156 | 0.71 | PREP (0.47) | NR2E1NSD2MEN1GAAKMT2A | |
| SCHEMBL28859700 | 0.71 | HDAC3 (0.43) | NSD2NPC1MAPTRAB9ADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |