Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5018836 | 0.79 | NFKB1 (0.38) | ALDH1A1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1162976 | 0.74 | KDM4E (0.38) | KDM4ECDK2ALDH1A1HPGDMAPT | |
| SCHEMBL31703186 | 0.74 | KDM4E (0.38) | KDM4ECDK2ALDH1A1HPGDMAPT | |
| SCHEMBL12120831 | 0.73 | NOS3 (0.39) | KDM4EALDH1A1HPGDCTSSCTSK | |
| SCHEMBL31127281 | 0.73 | KDM4E (0.36) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL7052498 | 0.73 | KDM4E (0.36) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL18068020 | 0.71 | NOS3 (0.38) | ALDH1A1MAPTRAB9ALMNANFKB1 | |
| SCHEMBL10204245 | 0.71 | LMNA (0.38) | ALDH1A1MAPTSMN1; SMN2HTTLMNA | |
| SCHEMBL9649536 | 0.71 | POLB (0.38) | KDM4EALDH1A1NPC1POLBRAB9A | |
| SCHEMBL10204243 | 0.69 | NOS2 (0.41) | KDM4ECDK2ALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210353606-A1 | PqsR INVERSE AGONISTS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2021-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210353606-A1 | PqsR INVERSE AGONISTS | QRFPR, P2RY11, QARS1 | KDM4E 3629/4885CDK2 2404/4885ERBB2 977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.