Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26173847 | 0.89 | NPSR1 (0.43) | KDM4EALDH1A1NPSR1MPORAB9A | |
| SCHEMBL31320223 | 0.83 | NPSR1 (0.61) | KDM4EALDH1A1NPSR1MPORAB9A | |
| SCHEMBL2459826 | 0.83 | NPSR1 (0.61) | KDM4EALDH1A1NPSR1MPORAB9A | |
| SCHEMBL23009236 | 0.83 | KMT2A (0.43) | KDM4EALDH1A1RAB9AADORA1MAPT | |
| SCHEMBL6695881 | 0.78 | MAPT (0.53) | KDM4EALDH1A1NPSR1ADORA1MAPT | |
| SCHEMBL12942514 | 0.75 | ALDH1A1 (0.47) | KDM4EALDH1A1RAB9AMAPTGAA | |
| SCHEMBL4104105 | 0.75 | KDM4E (0.65) | KDM4EALDH1A1NPSR1RAB9AMAPT | |
| SCHEMBL7055308 | 0.75 | KDM4E (0.55) | KDM4EALDH1A1NPSR1MPORAB9A | |
| SCHEMBL6692482 | 0.72 | MAPT (0.54) | KDM4EALDH1A1RAB9ACYP2D6ADORA1 | |
| SCHEMBL7056204 | 0.70 | LMNA (0.50) | KDM4EALDH1A1NPSR1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183187-A1 | QUINAZOLINE COMPOUNDS AS INHIBITORS OF PREMATURE TERMINATION CODONS | CENTRE NAT RECH SCIENT (FR) | 2023-06-15 | — | — | US | disclosed |
| US-20230183187-A1 | QUINAZOLINE COMPOUNDS AS INHIBITORS OF PREMATURE TERMINATION CODONS | CENTRE NAT RECH SCIENT (FR) | 2023-06-15 | — | — | US | disclosed |
| WO-2021228945-A1 | QUINAZOLINE COMPOUNDS AS INHIBITORS OF PREMATURE TERMINATION CODONS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2021-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183187-A1 | QUINAZOLINE COMPOUNDS AS INHIBITORS OF PREMATURE TERMINATION CODONS | UPF1, NUDT21, REV1 | KDM4E 2993/4885ALDH1A1 4190/4885NPSR1 3334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.