Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.44 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | MC5R | P33032 | 1/20 | 0.37 |
| ▸ | MC3R | P41968 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHRNA1 | P02708 | 3/20 | 0.34 |
| ▸ | CHRNG | P07510 | 3/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 3/20 | 0.34 |
| ▸ | CHRND | Q07001 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16247089 | 0.98 | SIGMAR1 (0.43) | SIGMAR1MC4RMC5RMC3RMEN1 | |
| SCHEMBL16429434 | 0.94 | CHRNA1 (0.41) | SIGMAR1MC4RMC5RMC3RCHRNA1 | |
| SCHEMBL18223042 | 0.91 | SIGMAR1 (0.39) | SIGMAR1MC4RMC5RMC3RMEN1 | |
| SCHEMBL18223038 | 0.90 | SIGMAR1 (0.38) | SIGMAR1MC4RMC5RMC3RMEN1 | |
| SCHEMBL15287732 | 0.89 | SIGMAR1 (0.47) | SIGMAR1MEN1KMT2ACHRNA1CHRNG | |
| SCHEMBL16266913 | 0.86 | SIGMAR1 (0.45) | SIGMAR1MC4RMC5RMC3RMEN1 | |
| SCHEMBL15287524 | 0.84 | SIGMAR1 (0.43) | SIGMAR1MC4RMC5RMC3RCHRNA1 | |
| SCHEMBL16428941 | 0.83 | SIGMAR1 (0.43) | SIGMAR1MC4RMC5RMC3RMEN1 | |
| SCHEMBL16247109 | 0.83 | SIGMAR1 (0.40) | SIGMAR1MEN1KMT2ATP53CYP1A2 | |
| Hydrochloric Acid SCHEMBL16247175 | 0.82 | SIGMAR1 (0.42) | SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10440955-B2 | Methods comprising a biocidal polyamine | CURZA GLOBAL, LLC (US) | 2019-10-15 | — | — | US | disclosed |
| US-20180125070-A1 | COMPOSITIONS AND METHODS COMPRISING A BIOCIDAL POLYAMINE | THE UNIVERSITY OF UTAH | 2018-05-10 | — | — | US | disclosed |
| EP-2539389-B1 | AMINE POLYMERS FOR USE AS BILE ACID SEQUESTRANTS | RELYPSA INC (US) | 2017-12-20 | — | — | EP | disclosed |
| US-9839219-B2 | Compositions comprising a biocidal polyamine | CURZA GLOBAL, LLC (US) | 2017-12-12 | — | — | US | disclosed |
| US-20170258825-A1 | AMINE POLYMERS FOR USE AS BILE ACID SEQUESTRANTS | RELYPSA, INC. | 2017-09-14 | — | — | US | disclosed |
| US-9655920-B2 | Amine polymers for use as bile acid sequestrants | RELYPSA, INC. (US) | 2017-05-23 | — | — | US | disclosed |
| US-20160330962-A1 | COMPOSITIONS COMPRISING A BIOCIDAL POLYAMINE | CURZA GLOBAL, LLC | 2016-11-17 | — | — | US | disclosed |
| US-9439433-B2 | Compositions and methods comprising a biocidal polyamine | CURZA GLOBAL, LLC (US) | 2016-09-13 | — | — | US | disclosed |
| EP-2999345-A1 | COMPOSITIONS AND METHODS COMPRISING A POLYAMINE | Curza Global LLC (US) | 2016-03-30 | — | — | EP | disclosed |
| US-20150038512-A1 | COMPOSITIONS AND METHODS COMPRISING A BIOCIDAL POLYAMINE | THE UNIVERSITY OF UTAH | 2015-02-05 | — | — | US | disclosed |
| US-20140356316-A1 | AMINE POLYMERS FOR USE AS BILE ACID SEQUESTRANTS | RELYPSA, INC. (US) | 2014-12-04 | — | — | US | disclosed |
| WO-2014190096-A1 | COMPOSITIONS AND METHODS COMPRISING A POLYAMINE | CURZA GLOBAL, LLC (US) | 2014-11-27 | — | — | WO | disclosed |
| EP-2539389-A1 | AMINE POLYMERS FOR USE AS BILE ACID SEQUESTRANTS | Relypsa, Inc. (US) | 2013-01-02 | — | — | EP | disclosed |
| WO-2011106548-A1 | AMINE POLYMERS FOR USE AS BILE ACID SEQUESTRANTS | RELYPSA, INC. (US) | 2011-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170258825-A1 | AMINE POLYMERS FOR USE AS BILE ACID SEQUESTRANTS | NR1H4, SLC10A2, SLC10A1 | SIGMAR1 1301/4885MC4R 775/4885MC5R 857/4885 |
| US-20160330962-A1 | COMPOSITIONS COMPRISING A BIOCIDAL POLYAMINE | SRM, SMS, SMOX | SIGMAR1 1551/4885MC4R 4796/4885MC5R 4354/4885 |
| US-20140356316-A1 | AMINE POLYMERS FOR USE AS BILE ACID SEQUESTRANTS | NR1H4, SLC10A2, SLC10A1 | SIGMAR1 1301/4885MC4R 775/4885MC5R 857/4885 |
| US-10440955-B2 | Methods comprising a biocidal polyamine | SRM, SMOX, SMS | SIGMAR1 1642/4885MC4R 4823/4885MC5R 4385/4885 |
| US-20180125070-A1 | COMPOSITIONS AND METHODS COMPRISING A BIOCIDAL POLYAMINE | SRM, SMOX, SMS | SIGMAR1 1771/4885MC4R 4831/4885MC5R 4420/4885 |
| US-20150038512-A1 | COMPOSITIONS AND METHODS COMPRISING A BIOCIDAL POLYAMINE | SRM, SMOX, SMS | SIGMAR1 1771/4885MC4R 4831/4885MC5R 4420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.