SCHEMBL24038693

SCHEMBL24038693

N#Cc1cc(F)cc(NC=O)c1

nearest known ligand 0.44

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 1/20 0.39
GPR35 Q9HC97 1/20 0.38
EGLN2 Q96KS0 1/20 0.36
PGR P06401 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL429152 0.81 ALDH1A1 (0.44)
SCHEMBL20040770 0.77 TAS2R14 (0.50) GPR35
SCHEMBL24131392 0.76 GRM5 (0.38) GRM5PGR
SCHEMBL28284734 0.74 GPR35 (0.56) GPR35
SCHEMBL56741 0.73 GRM5 (0.43) GRM5
SCHEMBL1421650 0.73 GRM5 (0.47) GRM5
SCHEMBL19121228 0.73 GRM5 (0.36) GRM5PGR
SCHEMBL30543026 0.73 GPR35 (0.50) GPR35
SCHEMBL3551683 0.73 GPR35 (0.50) GPR35EGLN2
SCHEMBL20560662 0.73 GPR35 (0.50) GPR35

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3985001-A1 PHARMACEUTICAL COMPOSITION USEFUL IN INHIBITING IDH1 Les Laboratoires Servier SAS (FR) 2022-04-20 EP disclosed
WO-2021228992-A1 NUCLIDE LABELLED H-TETRAZINES AND USE THEREOF FOR PET AND SPECT PRETARGETED IMAGING AND RADIONUCLIDE THERAPY RIGSHOSPITALET (DK) 2021-11-18 WO disclosed