Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.34 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7863855 | 0.85 | HTT (0.44) | LMNAKMT2AL3MBTL1PRKDCSMN1; SMN2 | |
| SCHEMBL29746806 | 0.85 | HTT (0.44) | LMNAKMT2AL3MBTL1PRKDCSMN1; SMN2 | |
| SCHEMBL7865553 | 0.81 | ALDH1A1 (0.51) | LMNAPRKDCMAPTHPGDERN1 | |
| SCHEMBL11490625 | 0.79 | LMNA (0.50) | LMNAKMT2AMEN1ERN1ALDH1A1 | |
| SCHEMBL7857418 | 0.78 | HTT (0.42) | LMNAL3MBTL1PRKDCSMN1; SMN2MAPT | |
| SCHEMBL7857299 | 0.78 | PRKDC (0.57) | LMNAL3MBTL1PRKDCSMN1; SMN2MAPT | |
| SCHEMBL14748435 | 0.77 | CRHBP (0.40) | LMNAKMT2AL3MBTL1PRKDCSMN1; SMN2 | |
| SCHEMBL584683 | 0.77 | ERN1 (0.61) | LMNAKMT2APRKDCMAPTMEN1 | |
| SCHEMBL47874 | 0.75 | KMT2A (0.57) | LMNAKMT2AL3MBTL1GFERSMN1; SMN2 | |
| SCHEMBL13220942 | 0.75 | ALDH1A1 (0.50) | LMNAKMT2AL3MBTL1GFERSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728167-B1 | A PROCESS FOR THE PREPARATION OF CRISABOROLE | OLON SPA (IT) | 2021-12-01 | — | — | EP | disclosed |