Sugi Predict

Sugi Predict / Compounds / SCHEMBL24065467

SCHEMBL24065467

SCHEMBL24065467

O=[N+]([O-])c1ccc(Oc2ccccc2)c(Cn2cncn2)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP19A1 P11511 5/20 0.54
▸ KDM4E B2RXH2 3/20 0.44
▸ TSHR P16473 2/20 0.44
▸ MEN1 O00255 2/20 0.44
▸ KMT2A Q03164 2/20 0.44
▸ MLNR O43193 1/20 0.44
▸ LMNA P02545 1/20 0.44
▸ MMP1 P03956 1/20 0.44
▸ MPO P05164 1/20 0.44
▸ CYP1A2 P05177 1/20 0.44
▸ GLA P06280 1/20 0.44
▸ CYP3A4 P08684 1/20 0.44
▸ ADORA3 P0DMS8 1/20 0.44
▸ MAPT P10636 1/20 0.44
▸ CYP2C9 P11712 1/20 0.44
▸ HPGD P15428 1/20 0.44
▸ TBXA2R P21731 1/20 0.44
▸ PTGS1 P23219 1/20 0.44
▸ SLC6A2 P23975 1/20 0.44
▸ APEX1 P27695 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30965485 1.00 CYP19A1 (0.54) CYP19A1KDM4ETSHRMEN1KMT2A
SCHEMBL30965469 0.83 CYP19A1 (0.55) CYP19A1KDM4ETSHRMEN1KMT2A
SCHEMBL24065461 0.83 CYP19A1 (0.55) CYP19A1KDM4ETSHRMEN1KMT2A
SCHEMBL24065504 0.80 KDM4E (0.47) CYP19A1KDM4ETSHRMEN1KMT2A
SCHEMBL30965508 0.80 KDM4E (0.47) CYP19A1KDM4ETSHRMEN1KMT2A
SCHEMBL24065510 0.80 CYP19A1 (0.83) CYP19A1KMT2AALDH1A1
SCHEMBL30965499 0.80 CYP19A1 (0.83) CYP19A1KMT2AALDH1A1
SCHEMBL8936751 0.79 CYP19A1 (0.40) CYP19A1KDM4ENPSR1PKMTDP1
SCHEMBL14864858 0.76 MAPT (0.58) CYP19A1KDM4ETSHRMEN1KMT2A
SCHEMBL23292617 0.75 MAPT (0.53) CYP19A1KDM4ETSHRMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112513032-B 4-Substituted phenyl-1, 3, 5-triazine derivatives as modulators of TRK receptors 阿泽克制药公司 2024-07-02 — — CN disclosed
US-11840524-B2 4-substituted phenyl-1,3,5-triazine derivatives as modulators of TrK receptors AlzeCure Pharma AB (SE) 2023-12-12 — — US disclosed
US-11840524-B2 4-substituted phenyl-1,3,5-triazine derivatives as modulators of TrK receptors AlzeCure Pharma AB (SE) 2023-12-12 — — US disclosed
US-20210371402-A1 4-SUBSTITUTED PHENYL-1,3,5-TRIAZINE DERIVATIVES AS MODULATORS OF TRK RECEPTORS AlzeCure Pharma AB (SE) 2021-12-02 — — US disclosed
CN-112513032-A 4-substituted phenyl-1, 3, 5-triazine derivatives as modulators of TRK receptors 阿泽克制药公司 2021-03-16 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11840524-B2 4-substituted phenyl-1,3,5-triazine derivatives as modulators of TrK receptors NTRK2, NTRK3, BDNF CYP19A1 1282/4885KDM4E 2426/4885TSHR 60/4885
US-20210371402-A1 4-SUBSTITUTED PHENYL-1,3,5-TRIAZINE DERIVATIVES AS MODULATORS OF TRK RECEPTORS NTRK2, NTRK3, BDNF CYP19A1 1282/4885KDM4E 2426/4885TSHR 60/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.