Sugi Predict

Sugi Predict / Compounds / SCHEMBL2407029

SCHEMBL2407029

SCHEMBL2407029

OB(c1ccc(Cl)c(F)c1)c1ccc(Cl)c(F)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TRPV6 Q9H1D0 6/20 0.46
▸ ORAI1 Q96D31 5/20 0.46
▸ ORAI2 Q96SN7 5/20 0.46
▸ ORAI3 Q9BRQ5 5/20 0.46
▸ KMO O15229 2/20 0.37
▸ TTR P02766 1/20 0.36
▸ ENPP2 Q13822 1/20 0.36
▸ RAPGEF4 Q8WZA2 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ MAPK1 P28482 1/20 0.34
▸ KCNQ3 O43525 2/20 0.33
▸ KCNQ2 O43526 2/20 0.33
▸ KCNE1 P15382 2/20 0.33
▸ KCNQ1 P51787 2/20 0.33
▸ KCNQ5 Q9NR82 1/20 0.33
▸ PCSK9 Q8NBP7 1/20 0.33
▸ SLC6A3 Q01959 1/20 0.33
▸ PPARG P37231 1/20 0.32
▸ PPARA Q07869 1/20 0.32
▸ SLC2A1 P11166 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29465759 0.86 TTR (0.50) KMOTTRENPP2
SCHEMBL310780 0.86 TTR (0.50) KMOTTRENPP2
SCHEMBL9872898 0.84 TTR (0.48) KMOTTRENPP2
SCHEMBL2407140 0.82 ORAI1 (0.46) TRPV6ORAI1ORAI2ORAI3KMO
SCHEMBL971806 0.78 HSD17B10 (0.46) TRPV6ORAI1ORAI2ORAI3TTR
SCHEMBL974659 0.78 TRPV6 (0.52) TRPV6ORAI1ORAI2ORAI3KMO
SCHEMBL9872902 0.76 RAPGEF4 (0.33) KMORAPGEF4MAPTMAPK1SLC6A3
SCHEMBL1138283 0.73 TRPV6 (0.46) TRPV6ORAI1ORAI2ORAI3KMO
SCHEMBL150261 0.69 — —
SCHEMBL12266213 0.68 TRPV6 (0.64) TRPV6ORAI1ORAI2ORAI3RAPGEF4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8853424-B2 Protein cross-linking inhibitor JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2014-10-07 — — US disclosed
US-8853424-B2 Protein cross-linking inhibitor JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2014-10-07 — — US disclosed
US-8853424-B2 Protein cross-linking inhibitor JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2014-10-07 — — US disclosed
US-20110212919-A1 PROTEIN CROSS-LINKING INHIBITOR JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2011-09-01 — — US disclosed
US-20110212919-A1 PROTEIN CROSS-LINKING INHIBITOR JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2011-09-01 — — US disclosed
US-20110212919-A1 PROTEIN CROSS-LINKING INHIBITOR JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2011-09-01 — — US disclosed
WO-2010018837-A2 PROTEIN CROSS-LINKING INHIBITOR 独立行政法人科学技術振興機構 (JP) 2010-02-18 — — WO disclosed
WO-2010018836-A2 POLYGLUTAMINE AGGREGATION INHIBITOR 独立行政法人科学技術振興機構 (JP) 2010-02-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110212919-A1 PROTEIN CROSS-LINKING INHIBITOR BAZ2B, PRMT1, BRIX1 TRPV6 4868/4885ORAI1 4605/4885ORAI2 3906/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.