Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.34 |
| ▸ | HTR6 | P50406 | 4/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RORA | P35398 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | RORB | Q92753 | 1/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2408646 | 0.93 | RORC (0.33) | DHODHPTGDR2HTR6CHRM5RORC | |
| SCHEMBL2412422 | 0.89 | PTGDR2 (0.34) | DHODHPTGDR2HTR6METCYP2C19 | |
| SCHEMBL4999141 | 0.88 | HTR6 (0.37) | DHODHPTGDR2HTR6CCNE1CDK2 | |
| SCHEMBL2410603 | 0.86 | HTR6 (0.33) | PTGDR2HTR6CHRM5METCYP2C19 | |
| SCHEMBL2409445 | 0.85 | ESR1 (0.39) | PTGDR2HTR6 | |
| SCHEMBL2411045 | 0.84 | PTGER2 (0.33) | PTGDR2HTR6RORCKDM4E | |
| SCHEMBL4420273 | 0.84 | HTR6 (0.36) | PTGDR2HTR6 | |
| SCHEMBL2413762 | 0.83 | SLC6A9 (0.35) | PTGDR2HTR6CHRM5RORC | |
| SCHEMBL2407589 | 0.83 | MET (0.39) | PTGDR2HTR6CHRM5MET | |
| SCHEMBL2407583 | 0.83 | SOS1 (0.36) | DHODHPTGDR2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364979-A1 | Pyrrole compounds | Takeda Pharmaceutical Company Limited (JP) | 2011-09-14 | — | — | EP | disclosed |
| EP-2114917-A2 | PYRROLE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008108380-A2 | PYRROLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-12 | — | — | WO | disclosed |