SCHEMBL2407663

SCHEMBL2407663

O=C1Cc2c(Cl)cccc2CN1Cc1c[nH]cn1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.33
CYP1A2 P05177 1/20 0.33
DRD2 P14416 1/20 0.32
DRD3 P35462 1/20 0.32
KCNH2 Q12809 1/20 0.32
ACHE P22303 1/20 0.32
ACE P12821 1/20 0.32
MMP13 P45452 1/20 0.32
NISCH Q9Y2I1 1/20 0.32
ADRA2A P08913 1/20 0.31
CYP2D6 P10635 1/20 0.31
ADRA2B P18089 1/20 0.31
ADRA2C P18825 1/20 0.31
ADRA1D P25100 1/20 0.31
ADRA1A P35348 1/20 0.31
ADRA1B P35368 1/20 0.31
AHR P35869 1/20 0.31
HTR4 Q13639 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30361133 1.00 TSHR (0.33) TSHRCYP1A2DRD2DRD3KCNH2
SCHEMBL13136745 0.76 TAAR1 (0.46)
SCHEMBL4970834 0.76 ALDH1A1 (0.47) DRD2DRD3ADRA2ACYP2D6ADRA2B
SCHEMBL16057972 0.73 DDB1 (0.39) DRD2DRD3ACHEPOLBKDM4E
SCHEMBL3529275 0.73 NOTUM (0.39) DRD2ADRA2ACYP2D6ADRA2BADRA2C
SCHEMBL3530642 0.73 NOTUM (0.39) DRD2DRD3ADRA2ACYP2D6ADRA2B
SCHEMBL2405422 0.71 SRD5A1 (0.36) DRD2DRD3KCNH2
SCHEMBL30361111 0.71 SRD5A1 (0.36) DRD2DRD3KCNH2
Hydrochloric Acid SCHEMBL3047348 0.71 SRD5A1 (0.35) DRD2DRD3KCNH2
SCHEMBL21708179 0.70 ACHE (0.34) DRD2DRD3KCNH2ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230277501-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION THE JOHNS HOPKINS UNIVERSITY 2023-09-07 US disclosed
US-20230033195-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION THE JOHNS HOPKINS UNIVERSITY 2023-02-02 US disclosed
US-20220265685-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION THE JOHNS HOPKINS UNIVERSITY 2022-08-25 US disclosed
US-11160785-B2 Methods and compositions for improving cognitive function AGENEBIO INC. (US) 2021-11-02 US disclosed
US-20210244709-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION THE JOHNS HOPKINS UNIVERSITY 2021-08-12 US disclosed
EP-3827820-A1 BRIVARACETAM FOR IMPROVING COGNITIVE FUNCTION The Johns Hopkins University (US) 2021-06-02 EP disclosed
US-10806717-B2 Methods and compositions for improving cognitive function THE JOHNS HOPKINS UNIVERSITY (US) 2020-10-20 US disclosed
US-10624875-B2 Methods and compositions for treating schizophrenia THE JOHNS HOPKINS UNIVERSITY (US) 2020-04-21 US disclosed
EP-3610890-A1 METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA The Johns Hopkins University (US) 2020-02-19 EP disclosed
US-10154988-B2 Methods and compositions for treating schizophrenia THE JOHNS HOPKINS UNIVERSITY (US) 2018-12-18 US disclosed
US-20140206667-A1 METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA THE JOHNS HOPKINS UNIVERSITY 2014-07-24 US disclosed
WO-2014078568-A1 METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA THE JOHNS HOPKINS UNIVERSITY (US) 2014-05-22 WO disclosed
EP-2672822-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION The Johns Hopkins University (US) 2013-12-18 EP disclosed
US-20120214859-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION THE JOHNS HOPKINS UNIVERSITY 2012-08-23 US disclosed
WO-2012109491-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION THE JOHNS HOPKINS UNIVERSITY (US) 2012-08-16 WO disclosed
US-20110212928-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION THE JOHNS HOPKINS UNIVERSITY (US) 2011-09-01 US disclosed
US-20100222326-A1 New Heterocyclic Derivatives Useful For The Treatment of CNS Disorders UCB PHARMA, S.A. (BE) 2010-09-02 US disclosed
EP-2152262-A2 NEW HETEROCYCLIC DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS UCB Pharma, S.A. (BE) 2010-02-17 EP disclosed
WO-2008132139-A2 NEW HETEROCYCLIC DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS UCB PHARMA S.A. (BE) 2008-11-06 WO disclosed
WO-2008132142-A2 NEW HETEROCYCLIC DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS UCB PHARMA S.A. (BE) 2008-11-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10806717-B2 Methods and compositions for improving cognitive function GRIN2A, CHRNA2, SYNGR2 TSHR 4626/4885CYP1A2 355/4885DRD2 2163/4885
US-10154988-B2 Methods and compositions for treating schizophrenia RAB2A, SYNGR2, GRIN2A TSHR 3206/4885CYP1A2 393/4885DRD2 1076/4885
US-20210244709-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION GRIN2A, CHRNA2, SYNGR2 TSHR 4626/4885CYP1A2 355/4885DRD2 2163/4885
US-11160785-B2 Methods and compositions for improving cognitive function BACE2, BACE1, GRIN2A TSHR 1591/4885CYP1A2 673/4885DRD2 650/4885
US-10624875-B2 Methods and compositions for treating schizophrenia RAB2A, SYNGR2, GRIN2A TSHR 3262/4885CYP1A2 1188/4885DRD2 901/4885
US-20140206667-A1 METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA RAB2A, SYNGR2, GRIN2A TSHR 3262/4885CYP1A2 1188/4885DRD2 901/4885
US-20100222326-A1 New Heterocyclic Derivatives Useful For The Treatment of CNS Disorders CNR2, CNR1, SLC18A2 TSHR 1696/4885CYP1A2 175/4885DRD2 85/4885
US-20120214859-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION GRIN2A, GRIN2D, SLC18A2 TSHR 3927/4885CYP1A2 1302/4885DRD2 691/4885
US-20230277501-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION GRIN2A, CHRNA2, SYNGR2 TSHR 4626/4885CYP1A2 355/4885DRD2 2163/4885
US-20220265685-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION BACE1, BACE2, ACHE TSHR 4373/4885CYP1A2 1045/4885DRD2 2980/4885
US-20110212928-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION BACE1, BACE2, ACHE TSHR 4373/4885CYP1A2 1045/4885DRD2 2980/4885
US-20230033195-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION GRIN2D, GRIN2A, SLC18A2 TSHR 3729/4885CYP1A2 1477/4885DRD2 859/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.