Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.35 |
| ▸ | PARP1 | P09874 | 7/20 | 0.34 |
| ▸ | TNKS | O95271 | 6/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 6/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24076279 | 0.88 | POLB (0.42) | POLBTSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL29426569 | 0.84 | MAPT (0.44) | POLBTSHRSMN1; SMN2PRMT5WDR77 | |
| SCHEMBL24076896 | 0.84 | MAPT (0.44) | POLBTSHRSMN1; SMN2PRMT5WDR77 | |
| SCHEMBL24076281 | 0.82 | POLB (0.40) | POLBTSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL29426515 | 0.78 | PARP1 (0.42) | POLBTSHRSMN1; SMN2PRMT5WDR77 | |
| SCHEMBL26732910 | 0.78 | PARP1 (0.42) | POLBTSHRSMN1; SMN2PRMT5WDR77 | |
| SCHEMBL22552265 | 0.76 | POLB (0.44) | POLBTSHRSMN1; SMN2CYP1A2PRMT5 | |
| SCHEMBL24076266 | 0.76 | POLB (0.44) | POLBTSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL30452337 | 0.76 | POLB (0.44) | POLBTSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL24076884 | 0.75 | MEN1 (0.47) | SMN1; SMN2PRMT5WDR77PARP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230202989-A1 | COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-29 | — | — | US | disclosed |
| US-20230202989-A1 | COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-29 | — | — | US | disclosed |
| WO-2021239885-A1 | COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2021-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230202989-A1 | COMPOUNDS | NLRP3, NLRP1, IL1B | POLB 3231/4885TSHR 4236/4885SMN1; SMN2 4739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.