Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | CDC25B | P30305 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7429994 | 0.88 | CASR (0.52) | ALDH1A1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL15057284 | 0.84 | HPGD (0.48) | ALDH1A1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4490577 | 0.84 | AKR1C3 (0.60) | ALDH1A1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4485291 | 0.83 | PARP14 (0.47) | KMT2AMEN1 | |
| SCHEMBL14435084 | 0.82 | KMT2A (0.59) | ALDH1A1KMT2ATSHRRAB9ASMN1; SMN2 | |
| SCHEMBL30353836 | 0.82 | KMT2A (0.59) | ALDH1A1KMT2ATSHRRAB9ASMN1; SMN2 | |
| SCHEMBL1543828 | 0.82 | RAB9A (0.67) | ALDH1A1KMT2ATSHRRAB9ASMN1; SMN2 | |
| SCHEMBL11088028 | 0.82 | AKR1C3 (0.47) | ALDH1A1RAB9APKMMAPTNPSR1 | |
| SCHEMBL20798155 | 0.81 | FPR3 (0.48) | ALDH1A1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6368466 | 0.81 | FPR3 (0.44) | ALDH1A1KMT2ARAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117580831-A | GRK2 inhibitors and uses thereof | 索纳塔治疗公司 | 2024-02-20 | — | — | CN | disclosed |
| US-20230009608-A1 | GRK2 INHIBITORS AND USES THEREOF | SONATA THERAPEUTICS, INC. | 2023-01-12 | — | — | US | disclosed |
| WO-2021242844-A1 | GRK2 INHIBITORS AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2021-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230009608-A1 | GRK2 INHIBITORS AND USES THEREOF | GRK2, GRK3, GRK1 | ALDH1A1 2765/4885KMT2A 1345/4885TSHR 2690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.