SCHEMBL240856

SCHEMBL240856

CC(C)(C)OC(=O)N1CCCC1c1nc2cc(Br)cnc2n1COCC[Si](C)(C)C

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.37
ALDH1A1 P00352 7/20 0.37
USP30 Q70CQ3 2/20 0.37
UCHL1 P09936 2/20 0.37
TSHR P16473 5/20 0.37
GPR119 Q8TDV5 2/20 0.36
MEN1 O00255 3/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
LMNA P02545 5/20 0.35
MAPT P10636 2/20 0.35
NPSR1 Q6W5P4 2/20 0.35
TP53 P04637 2/20 0.35
GLA P06280 1/20 0.35
HTT P42858 1/20 0.34
GAA P10253 1/20 0.34
CHEK2 O96017 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL240857 1.00 KMT2A (0.37) KMT2AALDH1A1USP30UCHL1TSHR
SCHEMBL1293621 0.90 TP53 (0.34) ALDH1A1USP30MAPTTP53
SCHEMBL12103970 0.88 GPR119 (0.38) KMT2AALDH1A1USP30TSHRGPR119
SCHEMBL2756298 0.88 GPR119 (0.38) KMT2AALDH1A1TSHRGPR119MEN1
SCHEMBL2756294 0.87 ALDH1A1 (0.35) KMT2AALDH1A1TSHRGPR119MEN1
SCHEMBL1293972 0.87 KMT2A (0.37) KMT2AALDH1A1USP30UCHL1TSHR
SCHEMBL1293973 0.87 KMT2A (0.37) KMT2AALDH1A1USP30UCHL1TSHR
SCHEMBL1293720 0.86 ALDH1A1 (0.37) KMT2AALDH1A1UCHL1TSHRGPR119
SCHEMBL1293721 0.86 ALDH1A1 (0.37) KMT2AALDH1A1UCHL1TSHRGPR119
SCHEMBL236869 0.86 KMT2A (0.41) KMT2AALDH1A1USP30TSHRMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230285378-A1 Anti-Viral Compounds ABBVIE INC. (US) 2023-09-14 US disclosed
EP-3438106-A1 ANTI-VIRAL COMPOUNDS AbbVie Ireland Unlimited Company (IE) 2019-02-06 EP disclosed
US-20190015402-A1 Anti-Viral Compounds ABBVIE INC. (US) 2019-01-17 US disclosed
EP-2499127-B1 HEPATITIS C VIRUS INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2018-09-05 EP disclosed
US-10039754-B2 Anti-viral compounds ABBVIE INC. (US) 2018-08-07 US disclosed
US-10028937-B2 Anti-viral compounds ABBVIE INC. (US) 2018-07-24 US disclosed
US-20170355689-A1 HEPATITIS C VIRUS INHIBITOR BRISTOL MYERS SQUIBB CO (US) 2017-12-14 US disclosed
US-9776981-B2 Hepatitis C virus inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2017-10-03 US disclosed
US-20170157104-A1 Anti-Viral Compounds ABBVIE INC. (US) 2017-06-08 US disclosed
US-20170157105-A1 Anti-Viral Compounds ABBVIE INC. (US) 2017-06-08 US disclosed
US-8921514-B2 Anti-viral compounds ABBVIE INC. (US) 2014-12-30 US disclosed
EP-2692346-A1 An antiviral 1-phenyl-2,5-dibenzimidazol-5-yl-pyrrolidine derivative Abbvie Inc. (US) 2014-02-05 EP disclosed
EP-2692726-A1 Anti-viral compounds Abbvie Inc. (US) 2014-02-05 EP disclosed
US-20130317213-A1 Hepatitis C Virus Inhibitors BRISTOL MYERS SQUIBB CO (US) 2013-11-28 US disclosed
US-20130115193-A1 Hepatitis C Virus Inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2013-05-09 US disclosed
US-20120172290-A1 Anti-Viral Compounds ABBOTT LABORATORIES (US) 2012-07-05 US disclosed
US-20120004196-A1 Anti-Viral Compounds Abbott Labaoratories (US) 2012-01-05 US disclosed
US-20110274648-A1 Hepatitis C Virus Inhibitors BRISTOL-MYERS SQUIBB COMPANY 2011-11-10 US disclosed
US-20110269956-A1 Hepatitis C Virus Inhibitors BRISTOL-MYERS SQUIBB COMPANY 2011-11-03 US disclosed
US-20110207699-A1 Anti-Viral Compounds Abbott Labaoratories (US) 2011-08-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170355689-A1 HEPATITIS C VIRUS INHIBITOR HAVCR2, LIPC, PYGL KMT2A 4482/4885ALDH1A1 1107/4885USP30 2386/4885
US-10028937-B2 Anti-viral compounds HAVCR2, EIF2AK2, MAVS KMT2A 4093/4885ALDH1A1 2858/4885USP30 1963/4885
US-20230285378-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS KMT2A 4093/4885ALDH1A1 2858/4885USP30 1963/4885
US-20130317213-A1 Hepatitis C Virus Inhibitors HAVCR2, HCCS, MAVS KMT2A 4479/4885ALDH1A1 1627/4885USP30 1552/4885
US-20170157105-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS KMT2A 4093/4885ALDH1A1 2858/4885USP30 1963/4885
US-20170157104-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS KMT2A 4093/4885ALDH1A1 2858/4885USP30 1963/4885
US-20110207699-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS KMT2A 4093/4885ALDH1A1 2858/4885USP30 1963/4885
US-20110269956-A1 Hepatitis C Virus Inhibitors HAVCR2, HCCS, MAVS KMT2A 4479/4885ALDH1A1 1627/4885USP30 1552/4885
US-20190015402-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS KMT2A 4093/4885ALDH1A1 2858/4885USP30 1963/4885
US-20120004196-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS KMT2A 4093/4885ALDH1A1 2858/4885USP30 1963/4885
US-20110274648-A1 Hepatitis C Virus Inhibitors HAVCR2, PYGL, HCCS KMT2A 4516/4885ALDH1A1 1144/4885USP30 2534/4885
US-20130115193-A1 Hepatitis C Virus Inhibitors HAVCR2, PYGL, HCCS KMT2A 4516/4885ALDH1A1 1144/4885USP30 2534/4885
US-20120172290-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS KMT2A 4093/4885ALDH1A1 2858/4885USP30 1963/4885
US-10039754-B2 Anti-viral compounds HAVCR2, EIF2AK2, MAVS KMT2A 4093/4885ALDH1A1 2858/4885USP30 1963/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.