Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | DAGLB | Q8NCG7 | 1/20 | 0.30 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.30 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2407587 | 0.93 | DHODH (0.34) | RORCPTGDR2HTR6CHRM5DHODH | |
| SCHEMBL2411045 | 0.92 | PTGER2 (0.33) | RORCPTGDR2PTGER2HTR6KDM4E | |
| SCHEMBL2408863 | 0.89 | GPBAR1 (0.33) | RORCPTGDR2PTGER2GPBAR1HTR6 | |
| SCHEMBL5005875 | 0.88 | HTR6 (0.35) | RORCPTGER2GPBAR1HTR6DHODH | |
| SCHEMBL2408012 | 0.87 | PTGDR2 (0.31) | RORCPTGDR2PTGER2HTR6 | |
| SCHEMBL2408643 | 0.83 | SOS1 (0.33) | RORCGPBAR1HTR6 | |
| SCHEMBL1832153 | 0.83 | PTGDR2 (0.32) | RORCPTGDR2 | |
| SCHEMBL1833794 | 0.83 | PTGDR2 (0.34) | PTGDR2CHRM5 | |
| SCHEMBL2412422 | 0.82 | PTGDR2 (0.34) | PTGDR2HTR6DHODH | |
| SCHEMBL1832666 | 0.82 | PTGDR2 (0.33) | RORCPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364979-A1 | Pyrrole compounds | Takeda Pharmaceutical Company Limited (JP) | 2011-09-14 | — | — | EP | disclosed |
| EP-2114917-A2 | PYRROLE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008108380-A2 | PYRROLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-12 | — | — | WO | disclosed |