Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 11/20 | 0.34 |
| ▸ | HTR6 | P50406 | 4/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
| ▸ | HTR1F | P30939 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2408863 | 0.93 | GPBAR1 (0.33) | PTGDR2HTR6 | |
| SCHEMBL2412432 | 0.93 | HTR6 (0.35) | PTGDR2HTR6HTR7 | |
| SCHEMBL2412131 | 0.90 | MET (0.40) | PTGDR2HTR6MET | |
| SCHEMBL2408074 | 0.89 | HTR6 (0.34) | PTGDR2HTR6 | |
| SCHEMBL2407587 | 0.89 | DHODH (0.34) | PTGDR2HTR6METCYP2C19DHODH | |
| SCHEMBL2412162 | 0.88 | PTGDR2 (0.32) | PTGDR2 | |
| SCHEMBL2410603 | 0.87 | HTR6 (0.33) | PTGDR2HTR6METCYP2C19LMNA | |
| SCHEMBL5008475 | 0.86 | HTR6 (0.38) | PTGDR2HTR6METCYP2C19DHODH | |
| SCHEMBL2409445 | 0.86 | ESR1 (0.39) | PTGDR2HTR6 | |
| SCHEMBL2411045 | 0.85 | PTGER2 (0.33) | PTGDR2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364979-A1 | Pyrrole compounds | Takeda Pharmaceutical Company Limited (JP) | 2011-09-14 | — | — | EP | disclosed |
| EP-2114917-A2 | PYRROLE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008108380-A2 | PYRROLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-12 | — | — | WO | disclosed |