Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20645808 | 0.74 | MAPK1 (0.36) | ALDH1A1SMN1; SMN2POLBRIPK1L3MBTL1 | |
| SCHEMBL7913180 | 0.73 | ALDH1A1 (0.32) | ALDH1A1POLB | |
| SCHEMBL31493006 | 0.69 | — | — | |
| SCHEMBL24283148 | 0.69 | — | — | |
| SCHEMBL23565132 | 0.69 | LMNA (0.32) | ALDH1A1LMNAPOLB | |
| SCHEMBL13312207 | 0.63 | KDM4E (0.69) | ALDH1A1KDM4EHTTSMN1; SMN2PIK3R1 | |
| SCHEMBL1815818 | 0.60 | KMO (0.42) | ALDH1A1HTTPIK3R1PIK3CAPOLB | |
| SCHEMBL21315407 | 0.59 | KCNK3 (0.33) | KDM4ESMN1; SMN2MAPK1TSHR | |
| SCHEMBL23645307 | 0.59 | POLB (0.31) | POLBMAPK1 | |
| SCHEMBL13063763 | 0.58 | ALDH1A1 (0.35) | ALDH1A1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3526219-B1 | BICYCLIC PYRIDONE LACTAMS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2021-12-15 | — | — | EP | disclosed |