Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24094174 | 0.81 | ROCK1 (0.46) | KMT2AMEN1MAPTNPC1POLB | |
| SCHEMBL24610275 | 0.81 | ALDH1A1 (0.38) | MAPK1TP53CDK1CCNB2CCNB1 | |
| SCHEMBL24094162 | 0.79 | CTDSP1 (0.39) | KMT2AMEN1MAPTMAPK1NPC1 | |
| SCHEMBL24094128 | 0.76 | PLG (0.34) | NPC1TP53RAB9ACYP1A2 | |
| SCHEMBL24094118 | 0.76 | PRMT5 (0.41) | KMT2AMEN1MAPTRAB9AEGFR | |
| SCHEMBL24610274 | 0.76 | HTR1D (0.32) | NPC1TP53RAB9AGSK3BCYP1A2 | |
| SCHEMBL24094240 | 0.76 | NPBWR1 (0.35) | MAPTNPC1TP53PKMHPGD | |
| SCHEMBL21217617 | 0.74 | KDR (0.54) | NPC1RAB9AGSK3AGSK3B | |
| SCHEMBL22967237 | 0.72 | CYP1A2 (0.43) | MAPTHPGDKDM4ECYP1A2CYP2C9 | |
| SCHEMBL14949180 | 0.72 | MAPT (0.53) | KMT2AMEN1MAPTMAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4026834-A1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | Redx Pharma Plc (GB) | 2022-07-13 | — | — | EP | disclosed |
| EP-3743420-B1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA PLC (GB) | 2021-12-15 | — | — | EP | disclosed |