Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 2/20 | 0.41 |
| ▸ | CDC25A | P30304 | 1/20 | 0.40 |
| ▸ | CDC25C | P30307 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.38 |
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
| ▸ | CCND1 | P24385 | 2/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.38 |
| ▸ | DDO | Q99489 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30380737 | 1.00 | PARP1 (0.48) | PARP1KDM4EFEN1DAOCDC25A | |
| SCHEMBL28999960 | 0.83 | PTGES (0.45) | CDK2CCNE2CDK4CCND1CCNE1 | |
| SCHEMBL30273162 | 0.83 | PTGES (0.45) | CDK2CCNE2CDK4CCND1CCNE1 | |
| SCHEMBL24121204 | 0.82 | MPO (0.38) | PARP1PDGFRBFGFR1KDR | |
| SCHEMBL30380822 | 0.82 | MPO (0.38) | PARP1PDGFRBFGFR1KDR | |
| SCHEMBL6783202 | 0.80 | FEN1 (0.42) | PARP1KDM4EFEN1DAOMEN1 | |
| SCHEMBL31552840 | 0.80 | PARP1 (0.43) | PARP1KDM4EKMT2AHPGDHTT | |
| SCHEMBL30273156 | 0.80 | PARP1 (0.50) | PARP1KDM4EDAOCDK2LMNA | |
| SCHEMBL31386900 | 0.80 | PARP1 (0.55) | PARP1KDM4EKMT2AHPGD | |
| SCHEMBL29203527 | 0.80 | PARP1 (0.41) | PARP1LMNAHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116075512-A | Heterocyclic compounds and imaging agents for imaging huntingtin | CHDI基金会股份有限公司 | 2023-05-05 | — | — | CN | disclosed |
| US-20210393812-A1 | HETEROCYCLIC COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2021-12-23 | — | — | US | disclosed |
| WO-2021252775-A1 | HETEROCYCLIC COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. (US) | 2021-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210393812-A1 | HETEROCYCLIC COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | HTT, HYPK, HSPBP1 | PARP1 3115/4885KDM4E 4698/4885FEN1 3894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.