Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 8/20 | 0.47 |
| ▸ | NPC1 | O15118 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL139209 | 0.95 | MDM2 (0.51) | MDM2CYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL8524430 | 0.93 | MDM2 (0.50) | MDM2CYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL27913095 | 0.89 | MDM2 (0.47) | MDM2CYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL4059081 | 0.88 | CYP1A2 (0.57) | MDM2CYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL27402049 | 0.85 | MDM2 (0.45) | MDM2CYP1A2CYP2D6CYP19A1CYP2C9 | |
| Carbamic Acid SCHEMBL29154176 | 0.84 | MDM2 (0.44) | MDM2CYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL16175776 | 0.84 | MDM2 (0.44) | MDM2CYP1A2CYP2D6CYP19A1CYP2C9 | |
| Tetrahydrofuran SCHEMBL27422789 | 0.82 | MDM2 (0.43) | MDM2CYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL5947673 | 0.82 | CYP1A2 (0.54) | CYP1A2CYP2D6CYP19A1CYP2C9CYP2C19 | |
| Oxazole SCHEMBL27278480 | 0.79 | RAB9A (0.43) | MDM2CYP1A2CYP2D6CYP19A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105130919-A | Method and equipment for preparing 4-(5-methyl-3-phenyl-4-isoxazolyl) benzenesulfonyl chloride | JIANGSU YIJIA MEDICINE CO LTD | 2015-12-09 | — | — | CN | claimed |
| CN-104193694-A | Method for preparing parecoxib sodium intermediate | CHENGDU XINJIE HI TECH DEV CO LTD | 2014-12-10 | — | — | CN | claimed |
| CN-110483430-B | Preparation method of isoxazole derivative | 上海应用技术大学 | 2023-02-10 | — | — | CN | disclosed |
| CN-105130919-A | Method and equipment for preparing 4-(5-methyl-3-phenyl-4-isoxazolyl) benzenesulfonyl chloride | JIANGSU YIJIA MEDICINE CO LTD | 2015-12-09 | — | — | CN | disclosed |
| CN-102884054-B | Fluoroalkyl-substituted 2-amidobenzimidazoles and the use thereof for boosting stress tolerance in plants | BAYER IP GMBH | 2015-01-14 | — | — | CN | disclosed |
| CN-104193694-A | Method for preparing parecoxib sodium intermediate | CHENGDU XINJIE HI TECH DEV CO LTD | 2014-12-10 | — | — | CN | disclosed |
| CN-103596947-A | 3- or 5 - bi phenyl - 4 - ylisoxazole - based compounds useful for the treatment of fibrosis, pain, cancer and respiratory, allergic, nervous system or cardiovascular disorders | AMIRA PHARMACEUTICALS INC | 2014-02-19 | — | — | CN | disclosed |
| CN-102884054-A | Fluoroalkyl-substituted 2-amidobenzimidazoles and the use thereof for boosting stress tolerance in plants | BAYER IP GMBH | 2013-01-16 | — | — | CN | disclosed |
| US-20110237595-A1 | DERIVATIVES OF HETEROARYL-ALKYLCARBAMATES, METHODS FOR THEIR PREPARATION AND USE THEREOF AS FATTY ACID AMIDO HYDROLASE ENZYME INHIBITORS | SANOFI-AVENTIS (FR) | 2011-09-29 | — | — | US | disclosed |
| CN-1578774-A | Process for preparing benzenesulfonyl compounds | PHARMACIA CORP (US) | 2005-02-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237595-A1 | DERIVATIVES OF HETEROARYL-ALKYLCARBAMATES, METHODS FOR THEIR PREPARATION AND USE THEREOF AS FATTY ACID AMIDO HYDROLASE ENZYME INHIBITORS | FAAH, FAAH2, CNR1 | MDM2 4206/4885CYP1A2 352/4885CYP2D6 271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.