Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15426339 | 0.81 | OPRL1 (0.37) | ALDH1A1KDM4ELMNAHTTNPSR1 | |
| SCHEMBL15423926 | 0.78 | FAAH (0.56) | ALDH1A1KDM4EFAAHOPRD1OPRK1 | |
| Simufilam SCHEMBL12627054 | 0.78 | MC4R (0.46) | ALDH1A1KDM4ELMNAHTTNPSR1 | |
| SCHEMBL15423927 | 0.77 | ALDH1A1 (0.47) | ALDH1A1KDM4ELMNAHTTGAA | |
| Simufilam SCHEMBL22361802 | 0.76 | MC4R (0.45) | ALDH1A1KDM4ELMNAHTTNPSR1 | |
| Simufilam SCHEMBL22361808 | 0.76 | MC4R (0.45) | ALDH1A1KDM4ELMNAHTTNPSR1 | |
| SCHEMBL12656278 | 0.76 | GSK3A (0.42) | ALDH1A1KDM4ELMNAHTTNPSR1 | |
| Simufilam SCHEMBL22361805 | 0.75 | MC4R (0.44) | ALDH1A1KDM4ELMNAHTTNPSR1 | |
| SCHEMBL15423954 | 0.75 | DRD4 (0.46) | ALDH1A1KDM4ELMNAHTTNPSR1 | |
| SCHEMBL24106950 | 0.75 | OPRD1 (0.46) | ALDH1A1KDM4ELMNAHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210389298-A1 | Alzheimer's Disease Assay in a Living Patient | PAIN THERAPEUTICS, INC. (US) | 2021-12-16 | — | — | US | disclosed |