Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM5 | Q9NZQ8 | 3/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7855227 | 0.77 | HTR2C (0.49) | ACHEHTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL29711708 | 0.75 | OPRM1 (0.49) | CHRNB2CHRNA4HTR2CHTR2AHTR2B | |
| SCHEMBL3142111 | 0.75 | OPRM1 (0.49) | CHRNB2CHRNA4HTR2CHTR2AHTR2B | |
| SCHEMBL18685556 | 0.75 | OPRM1 (0.49) | CHRNB2CHRNA4HTR2CHTR2AHTR2B | |
| SCHEMBL16982797 | 0.75 | OPRM1 (0.49) | CHRNB2CHRNA4HTR2CHTR2AHTR2B | |
| SCHEMBL25669497 | 0.74 | KDM4E (0.44) | TRPM5ACHE | |
| SCHEMBL13091074 | 0.73 | DRD2 (0.48) | TRPM5ACHECHRNB2CHRNA4HTR2C | |
| SCHEMBL25669506 | 0.72 | ALDH1A1 (0.47) | TRPM5 | |
| SCHEMBL20921756 | 0.71 | ACHE (0.43) | TRPM5ACHECHRNB2CHRNA4HTR2C | |
| SCHEMBL20921808 | 0.71 | ACHE (0.43) | TRPM5ACHECHRNB2CHRNA4HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021252295-A1 | PROCESS OF MAKING ROXADUSTAT | SUZHOU PENGXU PHARMATECH CO., LTD. (CN) | 2021-12-16 | — | — | WO | disclosed |