Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24118074 | 0.90 | SMN1; SMN2 (0.41) | GCGRSMN1; SMN2KMT2AMEN1CYP1A2 | |
| SCHEMBL24118337 | 0.84 | SMN1; SMN2 (0.41) | GCGRSMN1; SMN2KMT2AMEN1CYP1A2 | |
| SCHEMBL24117960 | 0.82 | HIF1A (0.47) | SMN1; SMN2KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL24118187 | 0.82 | IDO1 (0.56) | GCGRSMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL24118233 | 0.82 | IDO1 (0.56) | GCGRSMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL24118292 | 0.80 | RAB9A (0.46) | SMN1; SMN2KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL24118244 | 0.80 | ALDH1A1 (0.51) | SMN1; SMN2KMT2AMEN1L3MBTL1MAPT | |
| SCHEMBL24118612 | 0.78 | L3MBTL1 (0.40) | SMN1; SMN2KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL24118254 | 0.78 | FPR2 (0.48) | KMT2AMEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL24118272 | 0.78 | MEN1 (0.44) | SMN1; SMN2KMT2AMEN1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210393600-A1 | Novel [1.1.1] Bicyclo Compounds as Indoleamine 2,3-Dioxygenase Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2021-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210393600-A1 | Novel [1.1.1] Bicyclo Compounds as Indoleamine 2,3-Dioxygenase Inhibitors | IDO1, IDO2, TPH1 | GCGR 3754/4885SMN1; SMN2 2675/4885KMT2A 1464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.