Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4420273 | 0.93 | HTR6 (0.36) | HTR6PTGDR2HTR2AHTR2CHTR7 | |
| SCHEMBL2412422 | 0.93 | PTGDR2 (0.34) | HTR6PTGDR2HTR7 | |
| SCHEMBL2412131 | 0.91 | MET (0.40) | HTR6NFE2L2PTGDR2KMT2A | |
| SCHEMBL2408074 | 0.90 | HTR6 (0.34) | HTR6PTGDR2 | |
| SCHEMBL2408863 | 0.89 | GPBAR1 (0.33) | HTR6PTGDR2PTGER2 | |
| SCHEMBL2409876 | 0.88 | HTR6 (0.34) | HTR6PTGDR2HTR2AHTR2CHTR7 | |
| SCHEMBL5002833 | 0.88 | NFE2L2 (0.38) | HTR6NFE2L2PTGDR2HTR2AHTR2C | |
| SCHEMBL2409039 | 0.85 | RXFP1 (0.33) | PTGDR2RXFP1PTGER2 | |
| SCHEMBL2407589 | 0.85 | MET (0.39) | HTR6PTGDR2 | |
| SCHEMBL2412162 | 0.84 | PTGDR2 (0.32) | PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364979-A1 | Pyrrole compounds | Takeda Pharmaceutical Company Limited (JP) | 2011-09-14 | — | — | EP | disclosed |
| EP-2114917-A2 | PYRROLE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008108380-A2 | PYRROLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-12 | — | — | WO | disclosed |